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FLASH GENE

Symbol

IL1RN

contributors: mct - updated : 02-06-2015

HGNC name	interleukin 1 receptor antagonist
HGNC id	6000

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	with a secreted form and an alternatively spliced intracellular form

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 1760 - 177 - Rholeder V2 - - 1865 - 180 - Rholeder V3 - - 1802 V4 - - 1973 - 143 - Rholeder

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Digestive liver       moderately Endocrine pancreas       highly Nervous brain       moderately Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

IL-1 family

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular

basic FUNCTION

interleukin 1,receptor antagonist

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to ankylosing spondylitis to Chronic kidney disease (CKD) and periodontitis (PD)

Variant & Polymorphism other	allele 2 of a VNTR increasing the risk of ankylosing spondylitis
	association of IL1RN alleles with susceptibility to CKD and PD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS