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FLASH GENE

Symbol

AGTR1

contributors: mct - updated : 10-11-2017

HGNC name	angiotensin II receptor, type 1
HGNC id	336

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

RTD3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in benign prostatic hyperplasia tumoral     --other   AGT plays a role in the growth of AGTR1-positive breast cancer cells through PI3-kinase/Akt pathway activation constitutional       gain of function of EDNRB and AGTR1 in vascular smooth muscle cells in ischemic heart disease constitutional     --other   altered expression of AGTR1 and AGTR2 with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration

Susceptibility

contributing in association with ACE to the risk of coronary disease, to diabetic nephropathy and essential hypertension to development of retinopathy of prematurity (ROP) to fetal growth restriction syndrome to pediatric hypertrophic cardiomyopathy with poor outcome

Variant & Polymorphism SNP , repeat , other	increasing the risk of fetal growth restriction syndrome
	associated with progressive septal hypertrophy and left ventricular outflow tract obstruction in children with hypertrophic cardiomyopathy
	association between SNPs and the development of ROP

Candidate gene
Marker
Therapy target	therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
	targeting AGT/AGTR1 signaling could be a novel therapeutic for breast cancer

ANIMAL & CELL MODELS