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FLASH GENE
Symbol IL1R1 contributors: mct/npt - updated : 24-06-2010
HGNC name interleukin 1 receptor, type I
HGNC id 5993
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand binding domain composed of three Ig-like domain,
  • a short cytoplasmic domains required for signaling, homolog to Drosophila Toll (TIR domain)
    • HOMOLOGY
    Homologene
    FAMILY
  • IL-1 receptor subfamily
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text transmembrane protein
    basic FUNCTION
  • important mediator involved in many cytokine induced immune and inflammatory responses
  • master regulator of inflammation and innate immunity (Brissoni 2006)
  • regulating bone growth and mass through its central signaling
  • maintained significantly higher expression on activated regulatory T cells as compared to other T cell subsets (Mercer 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex after induction of IL1 and recruitment of IRAK through its association with IL1RAP
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA)
  • interacts with the ubiquitin-binding protein TOLLIP (required for sorting of IL1RI at late endosomes) (Brissoni 2006)
  • substrate for presenilin-dependent gamma-secretase cleavage (Elzinga 2009)
  • FREM1 is its co-receptor, which associates with the signaling receptor complex to enhance recruitment of MyD88 and control Ras-dependent amplification of NF-KB and inflammatory responses (Zhang 2010)
  • IL1B, IL1A both bind to the same IL1 receptor (IL1R1) and are potent proinflammatory cytokines
  • PIK3AP1 is a critical link between IL1R1 and the metabolic status of activated T cells that ultimately regulates the differentiation of inflammatory Th17 cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to osteoporotic fractures
  • to schizophrenia and bipolar disorder
    • Variant & Polymorphism repeat
  • 86bp repeat increased risk of osteoporotic fractures
  • VNTR allele 2 increasing risk of schizophrenia and bipolar disorder
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    protective effect of IL1R1 antagonist on pancreatic beta-cell survival and function
    ANIMAL & CELL MODELS