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FLASH GENE
Symbol IL1R1 contributors: mct/npt - updated : 24-06-2010
HGNC name interleukin 1 receptor, type I
HGNC id 5993
RNA
TRANSCRIPTS type messenger
text
  • with two alternatively spliced isoforms, one secreted and one cytoplasmic, cotranscripted and intergenically spliced with GALT
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4909 - 569 - Magrangeas, McMahan (1991)
    - - 3000 - - - Magrangeas (1998)
    chimeric protein with part of GALT fused with entire IL1R1 protein
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     stomach   highly
    Lymphoid/Immunespleen   highly
    Nervousbraindiencephalonhypothalamus lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ligand binding domain composed of three Ig-like domain,
  • a short cytoplasmic domains required for signaling, homolog to Drosophila Toll (TIR domain)
  • HOMOLOGY
    Homologene
    FAMILY
  • IL-1 receptor subfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text transmembrane protein
    basic FUNCTION
  • important mediator involved in many cytokine induced immune and inflammatory responses
  • master regulator of inflammation and innate immunity (Brissoni 2006)
  • regulating bone growth and mass through its central signaling
  • maintained significantly higher expression on activated regulatory T cells as compared to other T cell subsets (Mercer 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex after induction of IL1 and recruitment of IRAK through its association with IL1RAP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA)
  • interacts with the ubiquitin-binding protein TOLLIP (required for sorting of IL1RI at late endosomes) (Brissoni 2006)
  • substrate for presenilin-dependent gamma-secretase cleavage (Elzinga 2009)
  • FREM1 is its co-receptor, which associates with the signaling receptor complex to enhance recruitment of MyD88 and control Ras-dependent amplification of NF-KB and inflammatory responses (Zhang 2010)
  • IL1B, IL1A both bind to the same IL1 receptor (IL1R1) and are potent proinflammatory cytokines
  • PIK3AP1 is a critical link between IL1R1 and the metabolic status of activated T cells that ultimately regulates the differentiation of inflammatory Th17 cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to osteoporotic fractures
  • to schizophrenia and bipolar disorder
  • Variant & Polymorphism repeat
  • 86bp repeat increased risk of osteoporotic fractures
  • VNTR allele 2 increasing risk of schizophrenia and bipolar disorder
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    protective effect of IL1R1 antagonist on pancreatic beta-cell survival and function
    ANIMAL & CELL MODELS