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FLASH GENE

Symbol

CBR1

contributors: mct - updated : 02-02-2008

HGNC name	carbonyl reductase 1
HGNC id	1548

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	3.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	XRE elements mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	seeRUNX1 ,DCR

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 1245 - 277 - Colombe (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Nervous brain       highly   nerve       highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies	homolog to murine Cbr1
	homolog to C.elegans F20G2.1

Homologene

FAMILY

short chain dehydrogenases/reductases (SDR) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	NADPH-dependent oxidoreductase
	metabolizing endogenous and xenobiotic substrates such as the fever mediator, prostaglandin E2 (PGE2), and the anticancer anthracycline drug, daunorubicin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate , lipid/lipoprotein

signaling

metabolism of many carbonyl compounds, including antitumor anthracycline antibiotics

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH

protein

cell & other

REGULATION

induced by

BHA,beta-naphthoflavone,sudan 1

Other

regulated by the aryl hydrocarbon receptor (AHR)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Down Syndrome (DS) and Alzheimer's Disease (AD) brains

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS