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FLASH GENE
Symbol KLLN contributors: mct - updated : 03-12-2015
HGNC name killin, p53-regulated DNA replication inhibitor
HGNC id 37212
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • is not only necessary but also sufficient for TP53-induced apoptosis
  • tumor suppressor in breast carcinomas, which inhibits tumor growth and invasiveness
  • transcription factor that regulates the cell cycle and induces apoptosis in cancer cells
  • is an androgen-regulated gene
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CWS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    germline and somatic KLLN mutations in breast cancer dysregulate G2 arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLLN expression may be used in prostate carcinoma as a prognostic marker to predict outcome for intermediate risk patients, which could provide useful information for postoperative management
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    might be used as a potential prognostic marker and novel therapy target for breast carcinomas
    ANIMAL & CELL MODELS