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FLASH GENE
Symbol TRAPPC11 contributors: mct - updated : 03-11-2020
HGNC name trafficking protein particle complex 11
HGNC id 25751
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • important for complex integrity and anterograde membrane transport from the endoplasmic reticulum (ER) to the ER-to-Golgi intermediate compartment (ERGIC) in mammals
  • implicated in ER-to-Golgi trafficking at a very early stage
  • role for TRAPPC11 in lipid-linked oligosaccharides (LLOs) biosynthesis and protein glycosylation in addition to its established function in vesicle trafficking
  • has a role upstream of autophagosome formation during macroautophag
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2S
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS