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FLASH GENE

Symbol

TRAPPC11

contributors: mct - updated : 03-11-2020

HGNC name	trafficking protein particle complex 11
HGNC id	25751

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	54.30 kb     30 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021942 30 - 4561 NP_068761 - 1133 - 2011 21525244 NM_199053 32 - 4442 NP_951008 - 1086 - 2011 21525244

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic

basic FUNCTION	important for complex integrity and anterograde membrane transport from the endoplasmic reticulum (ER) to the ER-to-Golgi intermediate compartment (ERGIC) in mammals
	implicated in ER-to-Golgi trafficking at a very early stage
	role for TRAPPC11 in lipid-linked oligosaccharides (LLOs) biosynthesis and protein glycosylation in addition to its established function in vesicle trafficking
	has a role upstream of autophagosome formation during macroautophag

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LGMD2S

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS