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FLASH GENE

Symbol

PATL2

contributors: mct - updated : 16-11-2017

HGNC name	protein associated with topoisomerase II homolog 2 (yeast)
HGNC id	33630

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved N-terminal sequence,
	a proline-rich region,
	a Mid domain,
	a C-terminal domain
	lacks a region of about 150 aa in the N-terminal part following the A domain

HOMOLOGY

interspecies	ortholog to S. cerevisiae Pat1
	ortholog to yeast Pat1p

intraspecies

paralog to PATL1

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	expressed throughout the cytoplasm, where it has a reticular distribution, but does not accumulate in P bodies

basic FUNCTION	seems to play an important role in the germ line
	potential regulator of translation
	harbor RNA binding activity and resulting translational repression, but decapping activity has not been shown
	might play an important role in the process of human oocyte maturation and early embryonic development
	RNA-binding protein that acts as a translational repressor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS