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FLASH GENE
Symbol PATL2 contributors: mct - updated : 16-11-2017
HGNC name protein associated with topoisomerase II homolog 2 (yeast)
HGNC id 33630
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 1967 - 543 - 2007 17936923
- - 1882 - 354 - 2007 17936923
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal sequence,
  • a proline-rich region,
  • a Mid domain,
  • a C-terminal domain
  • lacks a region of about 150 aa in the N-terminal part following the A domain
  • HOMOLOGY
    interspecies ortholog to S. cerevisiae Pat1
    ortholog to yeast Pat1p
    intraspecies paralog to PATL1
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text expressed throughout the cytoplasm, where it has a reticular distribution, but does not accumulate in P bodies
    basic FUNCTION
  • seems to play an important role in the germ line
  • potential regulator of translation
  • harbor RNA binding activity and resulting translational repression, but decapping activity has not been shown
  • might play an important role in the process of human oocyte maturation and early embryonic development
  • RNA-binding protein that acts as a translational repressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS