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FLASH GENE

Symbol

PATL2

contributors: mct - updated : 16-11-2017

HGNC name	protein associated with topoisomerase II homolog 2 (yeast)
HGNC id	33630

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001145112 16 - 1967 NP_001138584 - 543 - 2007 17936923 NM_001330283 - - 1882 NP_001317212 - 354 - 2007 17936923

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

cells

System Cell Pubmed Species Stage Rna symbol Reproductive oocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved N-terminal sequence,
	a proline-rich region,
	a Mid domain,
	a C-terminal domain
	lacks a region of about 150 aa in the N-terminal part following the A domain

HOMOLOGY

interspecies	ortholog to S. cerevisiae Pat1
	ortholog to yeast Pat1p

intraspecies

paralog to PATL1

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	expressed throughout the cytoplasm, where it has a reticular distribution, but does not accumulate in P bodies

basic FUNCTION	seems to play an important role in the germ line
	potential regulator of translation
	harbor RNA binding activity and resulting translational repression, but decapping activity has not been shown
	might play an important role in the process of human oocyte maturation and early embryonic development
	RNA-binding protein that acts as a translational repressor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS