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FLASH GENE
Symbol RFK contributors: npt/ - updated : 04-01-2010
HGNC name riboflavin kinase
HGNC id 30324
Location 9q21.13      Physical location : 79.000.432 - 79.009.444
Synonym name
  • ATP: riboflavin 5'-phosphotransferase
  • flavokinase
    • Synonym symbol(s) RP11-422N19.2, FLJ11149, RIFK
    EC.number 2.7.1.26
    DNA
    TYPE functioning gene
    STRUCTURE 9.01 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2707 - 155 - Yazdanpanah (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • riboflavin kinase activity
  • catalyzing the phosphorylation of riboflavin (vitamin B2) to form FMN, an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds to both the TNFRSF1A-death domain and to p22(phox), the common subunit of NADPH oxidase isoforms (Yazdanpanah 2009)
    cell & other
    REGULATION
    activated by TNF (TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase) (Yazdanpanah 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS