| basic FUNCTION
| having ubiquitin hydrolase and ligase activities |
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involved in proteasomal degradation, a critical process for neuronal health |
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significant role in synaptic remodeling, most likely by modulating free monomeric ubiquitin levels in an activity-dependent manner  |
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catalyzing its own deubiquitination in an intramolecular manner |
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functions in maintaining normal synaptic structure in hippocampal neurons |
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plays a role in regulating principal pathways involved in oncogenesis |
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de-ubiquitinating enzyme with important functions in recycling of ubiquitin |
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negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation |
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required for the maintenance of the structure and function of the neuromuscular junctions and the loss of normal activity may result in neurodegeneration in the peripheral nervous system |
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plays a critical role in the maintenance of normal neuromuscular synaptic transmission |
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essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development |
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has dual functions, such as hydrolase activity on the chemical bonds formed by the C-terminal Gly of Ub and dimerization-dependent ubiquitin ligase activity |
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HTRA2-mediated cleavage of UCHL1 may play important roles in regulating the fine balance between cell growth and cell death |
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UCHL1 and HTRA2 pair may play important roles in regulating the balance between cell death and cell survival |
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is a neuron-restricted protein that acts as a deubiquitinating enzyme, ubiquitin ligase or monoubiquitin stabilizer (PMId: 23064229) |
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neuron-specific de-ubiquitinating enzyme and plays an important role in ubiquitin turnover through its C-terminal hydrolytic activity |
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is a novel regulator of the kinase activities of CDKs |
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is involved in podocyte injury and proteinuria |
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de-ubiquitinating enzyme that cleaves ubiquitin at its carboxyl terminal |
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may delay Alzheimer progression by regulating APP degradation in a long-term fashion |
