| 1 | HTATIP2, UCHL1
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| Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma
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| Nanok C, Jearanaikoon P, Proungvitaya S, Limpaiboon T.
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| Mol Med Rep. Mar;17(3):4145-4153. doi: 10.3892/mmr.2017.8319. Epub 2017 Dec 19. 2018
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| 2 | SPG79, UCHL1
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| Novel UCHL1 mutations reveal new insights into ubiquitin processing.
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| Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK.
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| Hum Mol Genet 26(6):1031-1040. doi: 10.1093/hmg/ddw391.
2017
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| 3 | GFAP, UCHL1
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| Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
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| Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP.
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| Sci Rep 6:28203. doi: 10.1038/srep28203.
2016
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| 4 | UCHL1
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| Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.
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| Brackeva B, De Punt V, Kramer G, Costa O, Verhaeghen K, Stangé G, Sadones J, Xavier C, Aerts JM, Gorus FK, Martens GA.
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| J Proteomics 117:156-67. doi: 10.1016/j.jprot.2015.01.009. Epub 2015 Jan 29.
2015
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| 5 | UCHL1
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| Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
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| Zhang M, Cai F, Zhang S, Zhang S, Song W.
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| Sci Rep 4:7298. doi: 10.1038/srep07298.
2014
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| 6 | UCHL1
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| Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target.
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| Powis RA, Mutsaers CA, Wishart TM, Hunter G, Wirth B, Gillingwater TH.
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| Neuropathol Appl Neurobiol 40(7):873-87. doi: 10.1111/nan.12168.
2014
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| 7 | UCHL1
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| Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system.
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| Coulombe J, Gamage P, Gray MT, Zhang M, Tang MY, Woulfe J, Saffrey MJ, Gray DA.
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| Front Aging Neurosci 6:129. doi: 10.3389/fnagi.2014.00129. eCollection 2014.
2014
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| 8 | UCHL1
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| Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
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| Pang L, Wu Y, Dong N, Xu DH, Wang DW, Wang ZH, Li XL, Bian M, Zhao HJ, Liu XL, Zhang N.
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| Clin Biochem 47(1-2):72-6. doi: 10.1016/j.clinbiochem.2013.09.015. Epub 2013 Sep 28.
2014
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| 9 | IAPP, UCHL1
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| UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
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| Costes S, Gurlo T, Rivera JF, Butler PC.
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| Autophagy 10(6):1004-14. doi: 10.4161/auto.28478.
2014
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| 10 | NDGOA, UCHL1
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| Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.
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| Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M.
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| Proc Natl Acad Sci U S A 110(9):3489-94. doi: 10.1073/pnas.1222732110. Epub 2013 Jan 28.
2013
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| 11 | UCHL1
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| The regulation of the UCH-L1 gene by transcription factor NF-κB in podocytes.
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| Zhang H, Sun Y, Hu R, Luo W, Mao X, Zhao Z, Chen Q, Zhang Z.
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| Cell Signal 25(7):1574-85. doi: 10.1016/j.cellsig.2013.03.018. Epub 2013 Apr 6. Erratum in: Cell Signal. 2014 Feb;26(2):460.
2013
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| 12 | CDK1, CDK4, CDK5, UCHL1
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| Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
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| Kabuta T, Mitsui T, Takahashi M, Fujiwara Y, Kabuta C, Konya C, Tsuchiya Y, Hatanaka Y, Uchida K, Hohjoh H, Wada K.
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| J Biol Chem 288(18):12615-26. doi: 10.1074/jbc.M112.435701. Epub 2013 Mar 29.
2013
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| 13 | CRTC2, MTOR, UCHL1
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| Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
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| Hussain S, Feldman AL, Das C, Ziesmer SC, Ansell SM, Galardy PJ.
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| Mol Cell Biol 33(6):1188-97. doi: 10.1128/MCB.01389-12. Epub 2013 Jan 7.
2013
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| 14 | SLC6A5, SLC6A9, UCHL1
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| Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.
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| de Juan-Sanz J, Núñez E, López-Corcuera B, Aragón C.
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| PLoS One 8(3):e58863. doi: 10.1371/journal.pone.0058863. Epub 2013 Mar 6.
2013
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| 15 | SPG79, UCHL1
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| Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.
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| Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M.
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| Proc Natl Acad Sci U S A 110(9):3489-94. doi: 10.1073/pnas.1222732110. Epub 2013 Jan 28.
2013
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| 16 | NCAM1, UCHL1
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| UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM.
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| Wobst H, Förster S, Laurini C, Sekulla A, Dreiseidler M, Höhfeld J, Schmitz B, Diestel S.
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| FEBS J 279(23):4398-409. doi: 10.1111/febs.12029. Epub 2012 Nov 8.
2012
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| 17 | PTK2, UCHL1
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| Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.
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| Frisan T, Coppotelli G, Dryselius R, Masucci MG.
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| FASEB J 26(12):5060-70. doi: 10.1096/fj.12-211946. Epub 2012 Aug 29.
2012
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| 18 | UCHL1
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| Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
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| Chu KY, Li H, Wada K, Johnson JD.
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| Diabetologia 55(1):128-40. doi: 10.1007/s00125-011-2323-1. Epub 2011 Oct 25.
2012
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| 19 | UCH1LAS, UCHL1
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| Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
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| Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S.
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| Nature 491(7424):454-7. doi: 10.1038/nature11508. Epub 2012 Oct 14.
2012
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| 20 | UCHL1, UCHL3
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| Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.
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| Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P.
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| J Cell Physiol Cell Physiol. 2011 Jul 12. doi: 10.1002/jcp.22931. [Epub ahead of print]
2011
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| 21 | HTRA2, UCHL1
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| The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death.
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| Park DW, Nam MK, Rhim H.
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| Biochem Biophys Res Commun 415(1):24-9. doi: 10.1016/j.bbrc.2011.09.148. Epub 2011 Oct 6.
2011
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| 22 | UCHL1
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| Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
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| Zetterberg M, Sjölander A, von Otter M, Palmér MS, Landgren S, Minthon L, Wallin A, Andreasen N, Blennow K, Zetterberg H.
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| Mol Neurodegener 5:11.PMID: 20302621 2010
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| 23 | UCHL1
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| Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation.
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| Ichikawa T, Li J, Dong X, Potts JD, Tang DQ, Li DS, Cui T.
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| Biochem Biophys Res Commun 391(1):852-6. Epub 2009 Nov 27.PMID: 19945429 2010
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| 24 | UCHL1
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| Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.
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| Chen F, Sugiura Y, Myers KG, Liu Y, Lin W.
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| Proc Natl Acad Sci U S A 107(4):1636-41. Epub 2010 Jan 4.PMID: 20080621 2010
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| 25 | UCHL1
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| Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis.
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| Ragland M, Hutter C, Zabetian C, Edwards K.
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| Am J Epidemiol 170(11):1344-57. Epub 2009 Oct 28. Review.PMID: 19864305 2009
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| 26 | UCHL1
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| Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
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| Bheda A, Shackelford J, Pagano JS.
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| PLoS One 4(8):e6764.PMID: 19707515 2009
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| 27 | UCHL1
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| Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
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| Cartier AE, Djakovic SN, Salehi A, Wilson SM, Masliah E, Patrick GN.
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| J Neurosci 29(24):7857-68.PMID: 19535597 2009
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| 28 | UCHL1, UCHL3
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| Ubiquitin dimers control the hydrolase activity of UCH-L3.
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| Setsuie R, Sakurai M, Sakaguchi Y, Wada K.
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| Neurochem Int 54(5-6):314-21. Epub 2008 Dec 25.
2009
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| 29 | PARK5, UCHL1
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| Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.
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| Kabuta T, Furuta A, Aoki S, Furuta K, Wada K.
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| J Biol Chem 283(35):23731-8. Epub 2008 Jun 12.
2008
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| 30 | UCHL1, PARK5
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| Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
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| Kabuta T, Setsuie R, Mitsui T, Kinugawa A, Sakurai M, Aoki S, Uchida K, Wada K.
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| Hum Mol Genet 17(10):1482-96. Epub 2008 Feb 4. 2008
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| 31 | UCHL1
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| Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1.
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| Meray RK, Lansbury PT Jr.
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| J Biol Chem 282(14):10567-75. Epub 2007 Jan 26. 2007
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| 32 | DYT3, FTDP17, FTDU17, FXTAS, LRRK2, MAPT, PARK1, PARK4, PARK5, PARK6, PARK7, PARK8, PINK1, PRKN, PSRP, SNCA, UCHL1
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| Genetics of Parkinson disease: paradigm shifts and future prospects.
|
| Farrer MJ.
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| Nat Rev Genet 7(4):306-18. 2006
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| 33 | UCHL1
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| Aberrantly regulated proteins in frontotemporal dementia.
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| Schweitzer K, Decker E, Zhu L, Miller RE, Mirra SS, Spina S, Ghetti B, Wang M, Murrell J.
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| Biochem Biophys Res Commun 348(2):465-72. Epub 2006 Jul 28. 2006
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| 34 | UCHL1
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| Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.
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| Lombardino AJ, Li XC, Hertel M, Nottebohm F.
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| Proc Natl Acad Sci U S A 102(22):8036-41. Epub 2005 May 23. 2005
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| 35 | UCHL1, CD38, SLC16A7, SLC17A5, PDGFRL, TXNRD1
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| Identification of genes involved in estrogenic action in the human prostate using microarray analysis.
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| Bektic J, Wrulich OA, Dobler G, Kofler K, Ueberall F, Culig Z, Bartsch G, Klocker H.
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| Genomics 83(1):34-44. 2004
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| 36 | UCHL1
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| UCHL1 is a Parkinson's disease susceptibility gene.
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| Maraganore DM, Lesnick TG, Elbaz A, Chartier-Harlin MC, Gasser T, Kruger R, Hattori N, Mellick GD, Quattrone A, Satoh J, Toda T, Wang J, Ioannidis JP, de Andrade M, Rocca WA; UCHL1 Global Genetics Consortium.
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| Ann Neurol 55(4):512-21. Erratum in: Ann Neurol. 2004 Jun;55(6):899. Toda, Taksushi [corrected to Toda, Tatsushi]. 2004
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| 37 | UCHL1, PARK5
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| The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
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| Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr.
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| Cell 111(2):209-18. 2002
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| 38 | CDKN1B, COPS5, UCHL1
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| Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
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| Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J.
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| Oncogene 21(19):3003-10. 2002
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| 39 | UCHL1
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| Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease.
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| Naze P, Vuillaume I, Destee A, Pasquier F, Sablonniere B.
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| Neurosci Lett 328(1):1-4. 2002
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| 40 | PARK5, UCHL1
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| Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues.
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| Bittencourt Rosas SL, Caballero OL, Dong SM, da Costa Carvalho Mda G, Sidransky D, Jen J.
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| Cancer Lett 170(1):73-9. 2001
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| 41 | UCHL1
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| Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
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| Kurihara LJ, Kikuchi T, Wada K, Tilghman SM.
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| Hum Mol Genet 10(18):1963-70. 2001
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| 42 | PARK1, PARK3, PARK4, PRKN, UCHL1
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| Progress in the clinical and molecular genetics of familial parkinsonism.
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| Kitada T, Asakawa S, Matsumine H, Hattori N, Shimura H, Minoshima S, Shimizu N, Mizuno Y.
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| Neurogenetics 2(4):207-18. 2000
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| 43 | UCHL1
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| PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
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| Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J.
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| Am J Pathol 155(3):711-5 1999
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| 44 | UCHL1
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| A bi-functional activator/repressor element required for transcriptional activity of the human UCH-L1 gene assembles a neuron-specific protein: single-strand DNA complex.
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| Trowern AR, Mann DA.
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| Neurosci Lett 272(1):25-8 1999
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| 45 | PARK4, UCHL1
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| The ubiquitin pathway in Parkinson's disease.
|
| Leroy E, et al.
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| Nature 395 : 451-452. 1998
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| 46 | UCHL1
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| The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14.
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| Edwards YH, et al.
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| Ann Hum Genet 55 : 273-278. 1991
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| 47 | UCHL1
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| The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.
|
| Wilkinson KD, et al.
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| Science 246 : 670-673. 1989
|