| maturation of GABAergic innervation and inhibition was accelerated in mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated and they showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity | |
early postnatal lethality of BDNF null mice |
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heterozygous BDNF(+/-) mice develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood |
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transgenic overexpression of BDNF in mouse has a facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala and antidepressant effects |
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BDNF(Val66Met/Val66Met) mice exhibited increased anxiety-related behaviors in stressful settings |