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FLASH GENE

Symbol

BDNF

contributors: mct/pgu/shn - updated : 14-07-2016

HGNC name	brain-derived neurotrophic factor
HGNC id	1033

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

WAGR

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   low RNA and protein levels in brain of Alzheimer and Huntington disease patients constitutional     --low   reduced expression of brain-derived neurotrophic factor in the cerebrospinal fluid samples of infants with Ondine's curse constitutional     --low   in patients with major depressive disorder constitutional     --over   during migraine attacks, and in cluster headache, further supporting the involvement of BDNF in the pathophysiology of these primary headaches constitutional     --low   in the caudal nucleus of the solitary tract in the sudden infant death syndrome constitutional     --low   significant decrease in BDNF expression and impairment of downstream signaling in the aged hippocampus

Susceptibility

to bipolar disorder and depression to obsessive -compulsive disorder to aberrant eating behaviors (anorexia and bulimia ) to obesity in WAGR to Parkinson disease to psychosis to schizophrenia to obesity

Variant & Polymorphism SNP	Val66Met is associated with alterations in brain anatomy and memory, and play a key role in genetic predispositions to anxiety and depressive disorders
	VAL66MET increasing the risk of Parkinson disease and psychosis
	associated to obesity risk

Candidate gene	blood BDNF levels could be used as a biomarker to validate drugs aimed at restoring the defective intracellular vesicular dynamics in HD (Huntington disease)
Marker	mature BDNF may serve as a biomarker for major depressive disorder
Therapy target	delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis
	System Type Disorder Pubmed neurology     manipulation of BDNF/TrkB signaling might have therapeutic efficacy in motor neuron diseases neurology neurodegenerative alzheimer neuroprotective effects of entorhinal BDNF administration in animal models of Alzheimer's disease, with extension of therapeutic benefits into the degenerating hippocampus neurology neurodegenerative alzheimer a potential therapy for Alzheimer's disease miscelleaneous senescence   , epigenetic or pharmacological enhancement of BDNF-NTRK2 signaling could be a promising strategy for reversing cognitive aging

ANIMAL & CELL MODELS

	maturation of GABAergic innervation and inhibition was accelerated in mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated and they showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity
	early postnatal lethality of BDNF null mice
	heterozygous BDNF(+/-) mice develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood
	transgenic overexpression of BDNF in mouse has a facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala and antidepressant effects
	BDNF(Val66Met/Val66Met) mice exhibited increased anxiety-related behaviors in stressful settings