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FLASH GENE
Symbol DHFRL1 contributors: mct - updated : 24-08-2012
HGNC name dihydrofolate reductase-like 1
HGNC id 27309
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to DHFR (92 p100)
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
text
  • localization of DHFRL1 to the mitochondria
    • basic FUNCTION
  • capable of the same translational autoregulation as DHFR by binding to its own mRNA
  • can not only regulate its own translation but may also play a role in the regulation of DHFR protein translation
  • primary role is to support mitochondrial DNA synthesis and replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • thymidylate biosynthesis pathway, composed of SHMT2, TYMS and DHFRL1 in mitochondria
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS