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FLASH GENE
Symbol DHFRL1 contributors: mct - updated : 24-08-2012
HGNC name dihydrofolate reductase-like 1
HGNC id 27309
Location 3q11.1      Physical location : 93.776.769 - 93.781.660
Synonym name
  • dihydrofolate reductase pseudogene 4
  • dihydrofolate reductase-like protein 1
    • Synonym symbol(s) FLJ16119, DHFRP4
    EC.number 1.5.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 5.30 kb     2 Exon(s)
    text structure intronless
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4047 - 187 - 2011 21876184
    2 - 3934 - 187 - 2011 21876184
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to DHFR (92 p100)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    text
  • localization of DHFRL1 to the mitochondria
    • basic FUNCTION
  • capable of the same translational autoregulation as DHFR by binding to its own mRNA
  • can not only regulate its own translation but may also play a role in the regulation of DHFR protein translation
  • primary role is to support mitochondrial DNA synthesis and replication
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • thymidylate biosynthesis pathway, composed of SHMT2, TYMS and DHFRL1 in mitochondria
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS