| protein
| may link RARRES3 and DNA-mediated intracellular innate signaling to the translocon |
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activated TMEM173, accompanied by TBK1, then undergoes dramatic autophagy-related trafficking involving ATG9 and associates with endosomes containing the transcription factors interferon regulatory factor 3 (IRF3) and NFKB |
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is an adaptor that links virus-sensing receptors to IRF3 activation  |
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RNF5 negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria |
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IFIT1, virus-induced protein is associated with TMEM173 |
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TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates TMEM173 to confer double-stranded DNA-mediated innate immune responses |
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DDX41 is an additional DNA sensor that depends on TMEM173 to sense pathogenic DNA |
|
innate immune sensor of cyclic dinucleotides |
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TRIM32 interacted with TMEM173A, and was located at the mitochondria and endoplasmic reticulum |
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MRE11A physically interacted with dsDNA in the cytoplasm and was required for activation of TMEM173 and IRF3 |
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phosphorylation of TMEM173 on S366 strongly prevents the transcriptional activity of IRF3 |
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CGAS-induced activation of TMEM173 also involves the activation of the NFKB1 and IRF3 pathways |
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TBK1 is a downstream kinase controlling dsDNA-mediated IRF3 and NFKB1 signaling dependent on TMEM173 |
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AMFR and INSIG1, an E3 ubiquitin ligase complex, then catalyzed the K27-linked polyubiquitination of TMEM173 |
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MAVS and TMEM173 transduce signals from the cytosolic nucleic acid sensors DDX58 and CGAS, respectively |
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unique innate immune activation cascade in which TBK1-IKBKB formed a positive feedback loop to assure robust cytokine production during CGAS-TMEM173 activation |
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loss of the CGAS-TMEM173 pathway may be required to evade Extrachromosomal telomere repeat (ECTR)-induced anti-proliferation effects and permit alternative lengthening of telomeres (ALT) development in cancer |
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STING1 activates ADAM17 and this activation produces soluble proinflammatory SEMA4D independently of the TBK1/IRF3-mediated transcriptional pathway |
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IFNA1-mediated deregulation of mitochondrial metabolism and impairment of autophagic degradation, leading to cytosolic accumulation of mtDNA that is sensed via stimulator of interferon genes (STING1) to promote induction of autoinflammatory Dendritic,cells |
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YIPF5 is a positive regulator of STING1 trafficking |
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TBK1 acts redundantly with IKBKE to drive NFKB1 upon STING1 activation |
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OTUD5 interacts with STING1, cleaves its K48-linked polyubiquitin chains, and promotes its stability |
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C9ORF72 regulates trafficking and lysosomal degradation of inflammatory mediators, including toll-like receptors (TLRs) and STING1, to affect inflammatory outputs |
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PLD3 and PLD4 regulate both endosomal TLR and cytoplasmic/STING1 nucleic acid sensing pathways |
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activation of STING1 inhibits cancer cell migration and invasion by suppressing PLAU |
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oxidative stress induces MUC5AC expression through mitochondrial damage-dependent STING1 signaling in human bronchial epithelial cells |
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mechanistically, SELENOK interacts with STING1 in the ER and promotes STING1 oligomerization, which in turn promotes its translocation from the ER to the Golgi |
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SELENOK deficiency suppresses STING1-dependent innate responses and facilitates viral replication |
