| 1 | PLAU, STING1
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| Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion.
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| Tan J, Ge Y, Zhang M, Ding M.
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| J Biol Chem. Jan;299(1):102779. doi: 10.1016/j.jbc.2022.102779. Epub 2022 Dec 7. 2023
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| 2 | SELENOK, STING1
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| Selenoprotein K enhances STING oligomerization to facilitate antiviral response.
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| Lv L, Chai L, Wang J, Wang M, Qin D, Song H, Fu Y, Zhao C, Jia J, Zhao W, Jia M.
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| PLoS Pathog. Apr 6;19(4):e1011314. doi: 10.1371/journal.ppat. 2023
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| 3 | MUC5AC, STING1
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| Oxidative stress induces MUC5AC expression through mitochondrial damage-dependent STING signaling in human bronchial epithelial cells.
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| Nishida Y, Yagi H, Ota M, Tanaka A, Sato K, Inoue T, Yamada S, Arakawa N, Ishige T, Kobayashi Y, Arakawa H, Takizawa T.
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| FASEB Bioadv. Feb 17;5(4):171-181. doi: 10.1096/fba.2022-00081. 2023
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| 4 | OTUD5, STING1
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| OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
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| Guo Y, Jiang F, Kong L, Wu H, Zhang H, Chen X, Zhao J, Cai B, Li Y, Ma C, Yi F, Zhang L, Liu B, Zheng Y, Zhang L, Gao C
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| Cell Mol Immunol. Aug;18(8):1945-1955. doi: 10.1038/s41423-020-00531-5. Epub 2020 Sep 2. 2021
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| 5 | C9orf72, STING1
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| Cellular and physiological functions of C9ORF72 and implications for ALS/FTD.
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| Pang W, Hu F.
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| J Neurochem. May;157(3):334-350. doi: 10.1111/jnc.15255. Epub 2020 Dec 18 2021
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| 6 | IKBKE, STING1, TBK1
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| TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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| Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D.
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| Cell Rep. Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. 2020
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| 7 | STING1, YIPF5
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| YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking.
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| Ran Y, Xiong MG, Xu ZS, Luo WW, Wang SY, Wang YY.
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| J Immunol. Sep 15;203(6):1560-1570. doi: 10.4049/jimmunol.1900387. Epub 2019 Aug 7 2019
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| 8 | ORF3, ORMDL3, STAT6, STING1
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| STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
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| Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP.
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| Exp Cell Res 370(2):498-505. doi: 10.1016/j.yexcr.2018.07.015. Epub 2018 Aug 1. 2018
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| 9 | ADAM17, SEMA4D, STING1
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| Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
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| Motani K, Kosako H.
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| J Biol Chem 293(20):7717-7726. doi: 10.1074/jbc.RA118.002175. Epub 2018 Apr 4.
2018
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| 10 | IFNA1, STING1
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| IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion.
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| Gkirtzimanaki K, Kabrani E, Nikoleri D, Polyzos A, Blanas A, Sidiropoulos P, Makrigiannakis A, Bertsias G, Boumpas DT, Verginis P.
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| Cell Rep 25(4):921-933.e5. doi: 10.1016/j.celrep.2018.09.001.
2018
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| 11 | CGAS, STING1
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| Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.
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| Chen YA, Shen YL, Hsia HY, Tiang YP, Sung TL, Chen LY.
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| Nat Struct Mol Biol at Struct Mol Biol. 2017 Nov 6. doi: 10.1038/nsmb.3498. [Epub ahead of print] 2017
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| 12 | CGAS, IKBKB, STING1, TBK1
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| NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
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| Fang R, Wang C, Jiang Q, Lv M, Gao P, Yu X, Mu P, Zhang R, Bi S, Feng JM, Jiang Z.
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| J Immunol 199(9):3222-3233. doi: 10.4049/jimmunol.1700699. Epub 2017 Sep 22. 2017
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| 13 | CGAS, STING1
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| Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children.
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| Wang ZS, Liu YL, Mi N, Duan DY.
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| Mol Immunol 87:76-85. doi: 10.1016/j.molimm.2017.04.007. Epub 2017 Apr 13. 2017
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| 14 | CGAS, DDX58, MAVS, STING1
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| Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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| Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ.
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| Science 347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29. 2015
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| 15 | AMFR, INSIG1, STING1
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| The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
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| Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.
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| Immunity 41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28. 2014
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| 16 | IRF3, STING1, TBK1
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| Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.
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| Abe T, Barber GN.
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| J Virol 88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5. 2014
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| 17 | IRF3, STING1, TBK1, ULK1
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| Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
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| Konno H, Konno K, Barber GN.
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| Cell 155(3):688-98. doi: 10.1016/j.cell.2013.09.049. Epub 2013 Oct 10. 2013
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| 18 | MRE11A, STING1
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| DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
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| Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T.
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| Proc Natl Acad Sci U S A 110(8):2969-74. doi: 10.1073/pnas.1222694110. Epub 2013 Feb 6. 2013
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| 19 | CGAS, IRF3, STING1
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| Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
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| Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.
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| PLoS One 8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013. 2013
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| 20 | STING1, TRIM32
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| TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.
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| Zhang J, Hu MM, Wang YY, Shu HB.
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| J Biol Chem 287(34):28646-55. doi: 10.1074/jbc.M112.362608. Epub 2012 Jun 28. 2012
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| 21 | STING1
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| Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.
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| Shang G, Zhu D, Li N, Zhang J, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L.
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| Nat Struct Mol Biol 19(7):725-7. doi: 10.1038/nsmb.2332. 2012
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| 22 | STING1
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| The structural basis for the sensing and binding of cyclic di-GMP by STING.
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| Huang YH, Liu XY, Du XX, Jiang ZF, Su XD.
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| Nat Struct Mol Biol 19(7):728-30. doi: 10.1038/nsmb.2333. 2012
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| 23 | STING1
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| Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
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| Shu C, Yi G, Watts T, Kao CC, Li P.
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| Nat Struct Mol Biol 19(7):722-4. doi: 10.1038/nsmb.2331. 2012
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| 24 | STING1
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| Cyclic di-GMP sensing via the innate immune signaling protein STING.
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| Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H.
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| Mol Cell 46(6):735-45. doi: 10.1016/j.molcel.2012.05.029. Epub 2012 Jun 14. 2012
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| 25 | STING1
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| STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
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| Tanaka Y, Chen ZJ.
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| Sci Signal 5(214):ra20. 2012
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| 26 | STING1
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| The STING in the tail for cytosolic DNA-dependent activation of IRF3.
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| Bowie A.
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| Sci Signal 5(214):pe9. 2012
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| 27 | DDX41, STING1
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| The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
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| Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ.
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| Nat Immunol 12(10):959-65. doi: 10.1038/ni.2091. Erratum in: Nat Immunol. 2012 Feb;13(2):196. 2011
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| 28 | STING1
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| STING is a direct innate immune sensor of cyclic di-GMP.
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| Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE.
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| Nature 478(7370):515-8. doi: 10.1038/nature10429. 2011
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| 29 | DDX41, STING1
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| STING-dependent signaling.
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| Barber GN.
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| Nat Immunol 12(10):929-30. doi: 10.1038/ni.2118. Erratum in: Nat Immunol. 2012 Feb;13(2):196. 2011
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| 30 | STING1, TRIM56
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| The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.
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| Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S.
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| Immunity 33(5):765-76. doi: 10.1016/j.immuni.2010.10.013. Epub 2010 Nov 11. 2010
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| 31 | STING1
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| ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
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| Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z.
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| Proc Natl Acad Sci U S A 106(21):8653-8. Epub 2009 May 11. 2009
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| 32 | IFIT1, STING1
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| ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
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| Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB.
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| Proc Natl Acad Sci U S A 106(19):7945-50. Epub 2009 Apr 28. 2009
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| 33 | RNF5, STING1
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| The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
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| Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB.
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| Immunity 30(3):397-407. doi: 10.1016/j.immuni.2009.01.008. Epub 2009 Mar 12. 2009
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| 34 | STING1
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| MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.
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| Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC.
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| Mol Cell Biol 28(16):5014-26. Epub 2008 Jun 16. 2008
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| 35 | STING1
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| STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
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| Ishikawa H, Barber GN.
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| Nature 455(7213):674-8. Epub 2008 Aug 24. 2008
|