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FLASH GENE

Symbol

FGF2

contributors: mct/shn - updated : 08-02-2019

HGNC name	fibroblast growth factor 2 (basic)
HGNC id	3676

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian, testicular, breast cancer constitutional     --over   overproduced in idiopathic pulmonary hypertension (IPH) and contributes to SMC hyperplasia in IPH constitutional     --over   in the AD brain constitutional     --low   FGF2 expression is decreased in HOXA10-deficient cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative huntington chorea potential therapy target in Huntington disease neurology neurodegenerative   virus-mediated FGF2 gene delivery has potential as an alternative therapy of Alzheimer disease and possibly other neurocognitive disorders

ANIMAL & CELL MODELS

	mice lacking FGF2 are viable and fertile but display abnormalities in the cytoarchitecture of the neocortex, most pronounced in the frontal motor-sensory area, and a significant reduction in neuronal density in most layers of the motor cortex (
	FGF-2-deficient mice display cerebral cortex defects at birthectopic parvalbumin-positive neurons are present in the hippocampal commissure and neuronal deficiencies are observed in the cervical spinal cord, and are hypotensive (
	markedly reduced platelike trabecular structures, lost of many connecting rods of trabecular bone are, and a profound decreased mineralization of bone marrow stromal cultures in the Fgf2(-/-) mice (
	anabolic action of PTH on bone formation is impaired in Fgf2-/- mice compared to wild type
	Fgf2(-/-) mice exhibited decreased thermal pain sensitivity in the hotplate-test