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FLASH GENE
Symbol CTNNA2 contributors: mct - updated : 09-06-2012
HGNC name catenin (cadherin-associated protein), alpha 2
HGNC id 2510
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Catna2
intraspecies homolog to vinculin
Homologene
FAMILY vinculin family
CATEGORY adhesion
SUBCELLULAR LOCALIZATION     plasma membrane,junction,desmosome
    intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • regulating cell adhesion and linking classical cadherins to the neuronal cytoskeleton
  • thought to play a major role in the folding and lamination of the cerebral cortex
  • cadherin-binding protein, widely expressed in the nervous system and playing a crucial role in cadherin-mediated cell-cell adhesion
  • has diverse roles in the organization of the central nervous system, but only in limited portions of the brain
  • essential for the regulation of cell–cell and cell–matrix interactions in tissues
  • regulates the structure of synaptic contacts and is essential for normal brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the E cadherin multiprotein complex
  • s2 constituent of desmosomal plaque
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significant decrease in expression among patient non-smokers compared to smokers, schizophrenic or not
    constitutional     --over  
    in the degeneration/regeneration processes of the muscle after nerve injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • promising candidate gene for schizophrenia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS