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FLASH GENE

Symbol

CTNNA2

contributors: mct - updated : 09-06-2012

HGNC name	catenin (cadherin-associated protein), alpha 2
HGNC id	2510

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001164883 17 - 3870 NP_001158355 - 860 - 2011 21708131 NM_004389 18 - 4005 NP_004380 - 905 widely expressed, expressed in all brain regions analyzed with higher levels in the olfactory tract, frontal lobe, infundibulum, cerebellum, ventral pons and caudate nucleus 2011 21708131 CTNNA2A CTNNA2B - - 2900 59.9 537 very high expression levels in the olfactory bulb, frontal, occipital and parietal cortex, infundibulum, corpus mammilare, dorsal medulla, hippocampus, amygdala, thalamus and pineal gland, and expressed at lower levels in several other brain regions, detectable at significantly lower levels in the cerebellum and liver 2011 21708131

EXPRESSION

Rna function	mRNAs were abundant in both dorsolateral prefrontal cortex and hippocampus, with a distinct neuronal localization, and also abundant in the granule cells of the dentate gyrus and pyramidal cells of Ammon horn
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex frontal cortex highly Homo sapiens   brain limbic system hippocampus     Homo sapiens   nerve         Homo sapiens Reproductive male system testis       Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Catna2

intraspecies

homolog to vinculin

Homologene

FAMILY

vinculin family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane,junction,desmosome
	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	regulating cell adhesion and linking classical cadherins to the neuronal cytoskeleton
	thought to play a major role in the folding and lamination of the cerebral cortex
	cadherin-binding protein, widely expressed in the nervous system and playing a crucial role in cadherin-mediated cell-cell adhesion
	has diverse roles in the organization of the central nervous system, but only in limited portions of the brain
	essential for the regulation of cell–cell and cell–matrix interactions in tissues
	regulates the structure of synaptic contacts and is essential for normal brain development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of the E cadherin multiprotein complex
	s2 constituent of desmosomal plaque

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   significant decrease in expression among patient non-smokers compared to smokers, schizophrenic or not constitutional     --over   in the degeneration/regeneration processes of the muscle after nerve injury

Susceptibility

Variant & Polymorphism

Candidate gene	promising candidate gene for schizophrenia
Marker
Therapy target

ANIMAL & CELL MODELS