| basic FUNCTION
| playing a role in forebrain and craniofacial development |
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playing a role during retinal cell differentiation and survival |
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in hippocampal precursors DLX2 promoted neurogenesis but not neural stem cell activation  |
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is one critical player in shifting TGFB from its tumour suppressive to its tumour-promoting functions |
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may be involved in tumor progression via the regulation of metabolic stress-induced necrosis |
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plays crucial roles in the development of the cranial neural crest stem cells derived craniofacial skeleton |
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HELT and DLX2 are key transcription factors that are sufficient to direct neuronal progenitors along a specific differentiation pathway at the expense of alternative lineage choices |
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DLX1/DLX2 homeobox genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate to GABA |
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DLX1 and DLX2 promote interneuron GABA synthesis, synaptogenesis, and dendritogenesis |
