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FLASH GENE
Symbol TRIM67 contributors: mct - updated : 04-02-2014
HGNC name tripartite motif-containing 67
HGNC id 31859
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • two B box-type zinc fingers
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • a fibronectin type-III domain
  • a B30.2/SPRY domain
    • HOMOLOGY
    interspecies homolog to murine Trim67 (94 pc)
    intraspecies homolog to TRIM9
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-I TRIM family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • regulates LPPR4 and PRKCSH, which is involved in the activation of RAS, suggesting that TRIM67 negatively regulates RAS in cell proliferation and differentiation of neural precursor cells
  • promotes ubiquitination of PRKCSH and then contributes to the proteasomal degradation of PRKCSH
  • may regulate RAS activity, whereas TRIM9 may regulate RHO activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • regulates RAS signaling via degradation of PRKCSH, leading to neural differentiation including neuritogenesis
  • TRIM67 may function as a negative regulator for PRKCSH, resulting in RAS inhibition via degradation of PRKCSH followed by growth arrest and neuritogenesis in neural precursor cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS