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FLASH GENE
Symbol TRIM67 contributors: mct - updated : 04-02-2014
HGNC name tripartite motif-containing 67
HGNC id 31859
Location 1q42.2      Physical location : 231.298.673 - 231.357.314
Synonym name TRIM9-like protein TNL
Synonym symbol(s) TNL, FLJ44831
DNA
TYPE functioning gene
STRUCTURE 58.64 kb     10 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 8522 83.7 783 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum specific Homo sapiens
 spinal cord   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • two B box-type zinc fingers
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • a fibronectin type-III domain
  • a B30.2/SPRY domain
  • HOMOLOGY
    interspecies homolog to murine Trim67 (94 pc)
    intraspecies homolog to TRIM9
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-I TRIM family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • regulates LPPR4 and PRKCSH, which is involved in the activation of RAS, suggesting that TRIM67 negatively regulates RAS in cell proliferation and differentiation of neural precursor cells
  • promotes ubiquitination of PRKCSH and then contributes to the proteasomal degradation of PRKCSH
  • may regulate RAS activity, whereas TRIM9 may regulate RHO activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • regulates RAS signaling via degradation of PRKCSH, leading to neural differentiation including neuritogenesis
  • TRIM67 may function as a negative regulator for PRKCSH, resulting in RAS inhibition via degradation of PRKCSH followed by growth arrest and neuritogenesis in neural precursor cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS