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FLASH GENE

Symbol

TRIM67

contributors: mct - updated : 04-02-2014

HGNC name	tripartite motif-containing 67
HGNC id	31859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001004342 10 - 8522 NP_001004342 83.7 783 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   specific Homo sapiens   spinal cord       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RING-type zinc finger
	two B box-type zinc fingers
	a coiled-coil domain
	a COS (C-terminal subgroup one signature) domain
	a fibronectin type-III domain
	a B30.2/SPRY domain

HOMOLOGY

interspecies

homolog to murine Trim67 (94 pc)

intraspecies

homolog to TRIM9

Homologene

FAMILY	TRIM/RBCC family
	C-I TRIM family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	regulates LPPR4 and PRKCSH, which is involved in the activation of RAS, suggesting that TRIM67 negatively regulates RAS in cell proliferation and differentiation of neural precursor cells
	promotes ubiquitination of PRKCSH and then contributes to the proteasomal degradation of PRKCSH
	may regulate RAS activity, whereas TRIM9 may regulate RHO activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	regulates RAS signaling via degradation of PRKCSH, leading to neural differentiation including neuritogenesis
	TRIM67 may function as a negative regulator for PRKCSH, resulting in RAS inhibition via degradation of PRKCSH followed by growth arrest and neuritogenesis in neural precursor cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS