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FLASH GENE

Symbol

IRS1

contributors: mct - updated : 21-03-2017

HGNC name	insulin receptor substrate 1
HGNC id	6125

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NIDDM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function enhances breast cancer metastasis and IRS1 has potentially metastasis suppressor functions for breast cancer constitutional     --low   in diabetes, IRS1 is down-regulated, and cells become resistant to insulin tumoral     --over   in breast cancer

Susceptibility

to type 2 or type 1 diabetes to polycystic ovary syndrome (PCOS) to high body mass index

Variant & Polymorphism SNP , other	polymorphism associated to susceptibility to obesity with insulin resistance and to type 1 diabetes (variant G972R)
	Gly972Arg polymorphism is associated with PCOS in the Japanese population
	C allele of rs2943641 is associated
	with increased T2D risk, fasting- and glucose-stimulated hyperinsulinemia and impaired insulin sensitivity
	body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and increased body mass index

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     new models to develop inhibitors against IRSs for anticancer therapy neurology acquired   IRS1 signaling is a therapeutic target for hypoxic brain injury in neonates

ANIMAL & CELL MODELS