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FLASH GENE
Symbol IRS1 contributors: mct - updated : 21-03-2017
HGNC name insulin receptor substrate 1
HGNC id 6125
ASSOCIATED DISORDERS
corresponding disease(s) NIDDM3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
enhances breast cancer metastasis and IRS1 has potentially metastasis suppressor functions for breast cancer
constitutional     --low  
in diabetes, IRS1 is down-regulated, and cells become resistant to insulin
tumoral     --over  
in breast cancer
Susceptibility
  • to type 2 or type 1 diabetes
  • to polycystic ovary syndrome (PCOS)
  • to high body mass index
  • Variant & Polymorphism SNP , other
  • polymorphism associated to susceptibility to obesity with insulin resistance and to type 1 diabetes (variant G972R)
  • Gly972Arg polymorphism is associated with PCOS in the Japanese population
  • C allele of rs2943641 is associated
  • with increased T2D risk, fasting- and glucose-stimulated hyperinsulinemia and impaired insulin sensitivity
  • body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and increased body mass index
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    new models to develop inhibitors against IRSs for anticancer therapy
    neurologyacquired 
    IRS1 signaling is a therapeutic target for hypoxic brain injury in neonates
    ANIMAL & CELL MODELS