Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

CD40

contributors: mct/npt - updated : 04-11-2015

HGNC name	CD40 molecule, TNF receptor superfamily member 5
HGNC id	11919

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HIGM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   during adipocyte differentiation constitutional     --other   aberrant CD40-induced NFKB1 activation in human lupus B lymphocytes

Susceptibility

to rheumatoid arthritis to Crohn disease and multiple sclerosis to variation of clinical disease manifestations in patients with systemic lupus erythematosus (SLE)

Variant & Polymorphism SNP , other	common variant increasing the risk of rheumatoid arthritis
	CD40 rs1883832 increasing the risk of Crohn disease and multiple sclerosis
	CD40 T variant might be negatively associated with some clinical disease manifestations in patients with SLE

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas CD40-dependent mechanism for targeting tumor stroma in the treatment of pancreatic cancer

ANIMAL & CELL MODELS

CD40-knocked-out mice