| 1 | CD40, DMD
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| Association Study of Exon Variants in the NF-κB and TGFβ Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy.
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| Bello L, Flanigan KM, Weiss RB; United Dystrophinopathy Project.
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| Am J Hum Genet 99(5):1163-1171. doi: 10.1016/j.ajhg.2016.08.023.
2016
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| 2 | CD40, SQSTM1, TRAF6
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| p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6.
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| Seibold K, Ehrenschwender M.
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| Biochem Biophys Res Commun 464(1):330-5. doi: 10.1016/j.bbrc.2015.06.153. Epub 2015 Jun 29.
2015
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| 3 | CD40, CD40LG, SPAG9
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| Scaffold protein JLP is critical for CD40 signaling in B lymphocytes.
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| Wang HM, Yan Q, Yang T, Cheng H, Du J, Yoshioka K, Kung SK, Ding GH.
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| J Biol Chem 290(9):5256-66. doi: 10.1074/jbc.M114.618496. Epub 2015 Jan 13.
2015
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| 4 | CD40, NEDD4, TRAF3
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| NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
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| Fang DF, He K, Wang N, Sang ZH, Qiu X, Xu G, Jian Z, Liang B, Li T, Li HY, Li AL, Zhou T, Gong WL, Yang B, Karin M, Zhang XM, Li WH.
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| Nat Commun 5:4513. doi: 10.1038/ncomms5513.
2014
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| 5 | CD40, PTPN6
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| SHP-1 plays a crucial role in CD40 signaling reciprocity.
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| Khan TH, Srivastava N, Srivastava A, Sareen A, Mathur RK, Chande AG, Musti KV, Roy S, Mukhopadhyaya R, Saha B.
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| J Immunol 193(7):3644-53. doi: 10.4049/jimmunol.1400620. Epub 2014 Sep 3.
2014
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| 6 | CD40
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| CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.
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| Schwartz MA, Kolhatkar NS, Thouvenel C, Khim S, Rawlings DJ.
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| J Immunol 193(7):3492-502. doi: 10.4049/jimmunol.1400798. Epub 2014 Aug 29.
2014
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| 7 | CD40, CD40LG, FAF1
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| Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop.
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| Elmetwali T, Young LS, Palmer DH.
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| Cell Death Dis 5:e1213. doi: 10.1038/cddis.2014.172.
2014
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| 8 | CD40
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| CD40-mediated maintenance of immune homeostasis in the adipose tissue microenvironment.
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| Yi Z, Stunz LL, Bishop GA.
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| Diabetes 63(8):2751-60. doi: 10.2337/db13-1657. Epub 2014 Mar 19.
2014
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| 9 | CD40, CD40LG
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| CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ADAM17 in a CD40 protein-dependent manner.
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| Yacoub D, Benslimane N, Al-Zoobi L, Hassan G, Nadiri A, Mourad W.
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| J Biol Chem 288(50):36083-93. doi: 10.1074/jbc.M113.506220. Epub 2013 Nov 4.
2013
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| 10 | CD40, HIGM3
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| Clinical, immunological, and molecular characterization of hyper-IgM syndrome due to CD40 deficiency in eleven patients.
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| Al-Saud BK, Al-Sum Z, Alassiri H, Al-Ghonaium A, Al-Muhsen S, Al-Dhekri H, Arnaout R, Alsmadi O, Borrero E, Abu-Staiteh A, Rawas F, Al-Mousa H, Hawwari A.
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| J Clin Immunol 33(8):1325-35. Review.
2013
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| 11 | CD40, TNFSF12, TRAF2
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| TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes.
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| Salzmann S, Lang I, Rosenthal A, Schäfer V, Weisenberger D, Carmona Arana JA, Trebing J, Siegmund D, Neumann M, Wajant H.
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| J Immunol 191(5):2308-18. doi: 10.4049/jimmunol.1202899. Epub 2013 Aug 5.
2013
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| 12 | CD40, CD40LG
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| Cysteine-rich domain 1 of CD40 mediates receptor self-assembly.
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| Smulski CR, Beyrath J, Decossas M, Chekkat N, Wolff P, Estieu-Gionnet K, Guichard G, Speiser D, Schneider P, Fournel S.
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| J Biol Chem 288(15):10914-22. doi: 10.1074/jbc.M112.427583. Epub 2013 Mar 5.
2013
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| 13 | CD40
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| Single nucleotide polymorphism of CD40 region and the risk of systemic lupus erythematosus.
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| Piotrowski P, Lianeri M, Wudarski M, Olesinska M, Jagodzinski PP.
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| Lupus 22(3):233-7. doi: 10.1177/0961203312470184. Epub 2012 Dec 20.
2013
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| 14 | CD40, SPAG9
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| A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells.
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| Wang H, Zhao C, Zhang M, Lee CM, Reddy EP, Kung SK.
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| Immunobiology 218(6):835-43. doi: 10.1016/j.imbio.2012.10.002. Epub 2012 Oct 13.
2013
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| 15 | CD40, CD40LG
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| Protein kinase C beta mediates CD40 ligand-induced adhesion of monocytes to endothelial cells.
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| Wu Z, Zhao G, Peng L, Du J, Wang S, Huang Y, Ou J, Jian Z.
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| PLoS One 8(9):e72593. doi: 10.1371/journal.pone.0072593. eCollection 2013.
2013
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| 16 | CD40, CD40LG, CHUK, NFKBIA
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| Involvement of nuclear factor κB in platelet CD40 signaling.
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| Hachem A, Yacoub D, Zaid Y, Mourad W, Merhi Y.
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| Biochem Biophys Res Commun 425(1):58-63. doi: 10.1016/j.bbrc.2012.07.049. Epub 2012 Jul 20.
2012
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| 17 | CD40
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| Aberrant CD40-induced NF-κB activation in human lupus B lymphocytes.
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| Zhang W, Shi Q, Xu X, Chen H, Lin W, Zhang F, Zeng X, Zhang X, Ba D, He W.
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| PLoS One 7(8):e41644. doi: 10.1371/journal.pone.0041644. Epub 2012 Aug 27.
2012
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| 18 | CD40
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| Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.
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| Song Z, Jin R, Yu S, Nanda A, Granger DN, Li G.
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| Arterioscler Thromb Vasc Biol 32(1):50-64. doi: 10.1161/ATVBAHA.111.238329. Epub 2011 Oct 13.
2012
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| 19 | CD40, CD40LG, SELE
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| CD40/CD40L interaction induces E-selectin dependent leukocyte adhesion to human endothelial cells and inhibits endothelial cell migration.
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| Urban D, Thanabalasingam U, Stibenz D, Kaufmann J, Meyborg H, Fleck E, Gräfe M, Stawowy P.
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| Biochem Biophys Res Commun 404(1):448-52. Epub 2010 Dec 5. 2011
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| 20 | CD40
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| CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.
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| Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, Torigian DA, O'Dwyer PJ, Vonderheide RH.
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| Science 331(6024):1612-6.
2011
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| 21 | CD40, RIPK1
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| The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas.
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| Knox PG, Davies CC, Ioannou M, Eliopoulos AG.
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| J Cell Biol 192(3):391-9. Epub 2011 Jan 31.
2011
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| 22 | CD40, TRAF3
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| Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signaling.
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| Peters AL, Bishop GA.
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| J Immunol 185(11):6555-62. Epub 2010 Nov 1.
2010
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| 23 | CD40
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| CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility.
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| Blanco-Kelly F, Matesanz F, Alcina A, Teruel M, Díaz-Gallo LM, Gómez-García M, López-Nevot MA, Rodrigo L, Nieto A, Cardeña C, Alcain G, Díaz-Rubio M, de la Concha EG, Fernandez O, Arroyo R, Martín J, Urcelay E.
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| PLoS One 5(7):e11520. Erratum in: PLoS One. 2010;5(8). doi: 10.1371/annotation/4d830d1b-46ff-4d72-b577-6a3765d335fc.
2010
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| 24 | CD40, CD40LG
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| Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
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| Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M.
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| J Immunol 185(1):220-30. Epub 2010 May 26. Erratum in: J Immunol. 2010 Aug 15;185(4):2631.
2010
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| 25 | CD40, CD40LG
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| The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.
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| Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J.
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| Am J Pathol 176(4):1816-27. Epub 2010 Feb 4.
2010
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| 26 | CD40, CD40LG, HIGM3
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| A novel mutation in CD40 and its functional characterization.
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| Qi CJ, Zheng L, Ma HB, Fei M, Qian KQ, Shen BR, Wu CP, Vihinen M, Zhang XG.
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| Hum Mutat 30(6):985-94. 2009
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| 27 | CD40
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| CD40-independent engagement of mammalian hsp70 by antigen-presenting cells.
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| Binder RJ.
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| J Immunol 182(11):6844-50.
2009
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| 28 | CD40, TRAF3
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| TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.
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| Jabara HH, Weng Y, Sannikova T, Geha RS.
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| Int Immunol 21(4):477-88. Epub 2009 Feb 19.
2009
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| 29 | CD40
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| The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.
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| Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M, Grino M, Stepanian A, Msika S, Burcelin R, de Prost D, Tanti JF, Alessi MC.
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| Diabetologia 52(6):1152-63. Epub 2009 Jan 31.
2009
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| 30 | CD40
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| OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions.
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| Hill KS, Errington F, Steele LP, Merrick A, Morgan R, Selby PJ, Georgopoulos NT, O'Donnell DM, Melcher AA.
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| J Immunol 181(5):3108-15.
2008
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| 31 | CD40, CDK6, MMEL1, PRKCQ
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| Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
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| Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.
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| Nat Genet 40(10):1216-23. Epub 2008 Sep 14.
2008
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| 32 | CD40
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| A novel polymorphism of the human CD40 receptor with enhanced function.
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| Peters AL, Plenge RM, Graham RR, Altshuler DM, Moser KL, Gaffney PM, Bishop GA.
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| Blood 112(5):1863-71. Epub 2008 Jun 30.
2008
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| 33 | CD40
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| CD40 mediates retinal inflammation and neurovascular degeneration.
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| Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carlson EC, Kern TS, Subauste CS.
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| J Immunol 181(12):8719-26.
2008
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| 34 | CD40
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| Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.
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| Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A.
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| Proc Natl Acad Sci U S A 98(22):12614-9. 2001
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| 35 | CD40
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| Molecular characterization of CD40 signaling intermediates
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| Werneburg BG, Zoog SJ, Dang TT, Kehry MR, Crute JJ.
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| J Biol Chem 276(46):43334-42. 2001
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| 36 | CD40, TRAF5
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| Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40.
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| Tsukamoto N, et al.
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| Proc Natl Acad Sci U S A 96 : 1234-1239. 1999
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| 37 | CD40, TRAF2
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| Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation.
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| Lee HH, et al.
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| Proc Natl Acad Sci U S A 96(4):1421-6. 1999
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| 38 | CD40LG, HIGM1, CD40
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| An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome).
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| Webster EA, et al.
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| Arthritis Rheum 42(6):1291-6. 1999
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| 39 | BCL2A1, CD40
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| NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.
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| Lee HH, Dadgostar H, Cheng Q, Shu J, Cheng G.
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| Proc Natl Acad Sci U S A 96(16):9136-41. 1999
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| 40 | CD40, CD27, TRAF5
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| Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.
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| Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, Munechika E, Sakai T, Shirasawa T, Akiba H, Kobata T, Santee SM, Ware CF, Rennert PD, Taniguchi M, Yagita H, Okumura K.
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| Proc Natl Acad Sci U S A 96(17):9803-8. 1999
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| 41 | CD40
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| Reduction of atherosclerosis in mice by inhibition of CD40 signalling.
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| Mach F, Schonbeck U, Sukhova GK, Atkinson E, Libby P.
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| Nature 394(6689):200-3. 1998
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| 42 | CD40, TSG20A
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| The human CD40 gene lies within chromosome 20q deletions associated with myeloid malignancies.
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| Asimakopoulos FA, et al.
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| Br J Haematol 92 : 127-130. 1996
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| 43 | CD40
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| Localization of the human CD40 gene to chromosome 20, bands q12-q13.2.
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| Lafage-Pochitaloff M, et al.
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| Leukemia 8 : 1172-1175. 1994
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| 44 | CD40
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| Chromosomal localization of the gene for human B-cell antigen CD-40.
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| Ramesh N, et al.
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| Somat Cell Mol Genet 19 : 295-298. 1993
|