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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

IMPDH2

contributors: mct - updated : 20-04-2015

HGNC name	IMP (inosine monophosphate) dehydrogenase 2
HGNC id	6053

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in osteosarcoma patients with poor response to chemotherapy

Susceptibility

to resistance to immunosuppressive drug, mycophenolic acid (MPA)

Variant & Polymorphism SNP	increasing the risk of resistance to immunosuppressive drug, mycophenolic acid (MPA)(

Candidate gene
Marker	may be a protein biomarker in colorectal cancer (
Therapy target
	System Type Disorder Pubmed cancer bone   targeting of IMPDH2 by RNAi or more effective pharmacological inhibitors in combination with chemotherapy might be a promising means of overcoming chemoresistance in osteosarcomas with high IMPDH2 expression cancer digestive colon novel therapeutic target in colorectal cancer

ANIMAL & CELL MODELS