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FLASH GENE

Symbol

NF2

contributors: mct/shn - updated : 11-12-2016

HGNC name	neurofibromin 2
HGNC id	7773

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Nf2 hemizygous mice do not develop schwannomas but mainly osteosarcomas
	conditional homozygous Nf2 knockout mice showed characteristics of neurofibromatosis type 2 including schwannomas, Schwann cell hyperplasia, cataract, and osseous metaplasia
	Mice with conditional deletion of exon 2 in Schwann cells develop schwannomas
	Nf2 deficiency in primary cells is an inability to undergo contact-dependent growth arrest and to form stable cadherin-containing cell:cell junctions