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FLASH GENE
Symbol NF2 contributors: mct/shn - updated : 11-12-2016
HGNC name neurofibromin 2
HGNC id 7773
ANIMAL & CELL MODELS
  • Nf2 hemizygous mice do not develop schwannomas but mainly osteosarcomas
  • conditional homozygous Nf2 knockout mice showed characteristics of neurofibromatosis type 2 including schwannomas, Schwann cell hyperplasia, cataract, and osseous metaplasia
  • Mice with conditional deletion of exon 2 in Schwann cells develop schwannomas
  • Nf2 deficiency in primary cells is an inability to undergo contact-dependent growth arrest and to form stable cadherin-containing cell:cell junctions