motifs/domains
| a globular N terminus with the FERM (EPB41, ezrin, radixin, moesin) domain, which are spliced out in isoforms Mer150/151/, and abolition of FERM domain-mediated phosphoinositide binding of merlin displaces merlin from the membrane and releases it into the cytosol without altering the folding of merlin  |
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two tubulin-binding sites, one residing at the N-terminal FERM-domain and another at the C-terminal domain |
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an alpha helical domain |
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a nuclear localization signal (NLS) and Mer162 interacting with actin-based cytoskeletal structures, through the binding of its isoform 2 to fodrin (SPTBN1) |
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two putative terminal binding sequence PBD1 and PBD2 (to binding with PXN) |
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broad C-terminal region (AA 141-595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RALGDS |
| basic FUNCTION
| involved in tumor suppression (see TSG22A) |
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responding and participating in reorganization of membrane-cytoplasmic interactions |
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regulating cell-growth, actin-cytoskeleton-mediated functions such as spreading, motility and attachement |
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involved in the maintenance of normal cytoskeletal organization |
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playing a role in receptor-mediated signaling at the cell surface, and may have implications in the regulation of cytoskeletal reorganization |
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plays a key role in the regulation of the Schwann cell microtubule cytoskeleton |
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indirectly regulates cellular pathways involved in tumorigenesis, including cell to cell adhesion, cytoskeletal architecture, and membrane protein organization |
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can mediate contact-dependent inhibition of proliferation by coordinating the establishment of cell:cell contact with down-regulation of EGFR signaling |
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functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact |
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inhibits the activation of Pak1 |
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plays a role in governing the hematopoietic stem cell pool by stem cell-autonomous or niche-determined processes |
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potent inhibitor of high-grade human glioma |
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may regulate receptor tyrosine kinase signaling, intracellular mitogenic growth control pathways, or adherens junction organization in non-nervous-system cell types |
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competitively inhibits Src binding to ERBB2 and, prevents ERBB2-mediated Src phosphorylation and downstream mitogenic signaling |
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regulates transmembrane receptors (such as ERB2 and ERB3) accumulation and signaling at the plasma membrane |
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negative regulator of MTOR, which activation is associated with meningioma and Schwannoma growth |
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inhibits mitogenic signaling at or near the plasma membrane |
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suppresses tumorigenesis by translocating to the nucleus to inhibit VPRBP |
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suppresses tumorigenesis by binding to VPRBP and suppressing its E3 ubiquitin ligase activity |
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can control the abundance and signaling of membrane receptors such as EGFR |
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playing a critical role in controlling homeostasis of the liver stem cell niche |
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may function to coordinate physical contacts and growth factor signaling among different cell types in this unique setting of intercellular communication |
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a role for Merlin in impeding breast malignancy |
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changes in the phosphorylation levels of NF2 and MSN lead likely to changes in epithelial organization |
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important and evolutionarily conserved molecular function of NF2 is to promote the membrane association of LATS1/LATS2 |
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regulates contact inhibition and is an integral part of cell-cell junctions |
