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FLASH GENE

Symbol

ALK

contributors: mct/shn - updated : 14-11-2013

HGNC name	anaplastic lymphoma receptor tyrosine kinase
HGNC id	427

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Forced expression of wild-type ALK and Neuroblastoma-related constitutively active ALK mutants in cultures of proliferating immature sympathetic neurons results in a strong proliferation increase, whereas Alk knockdown and pharmacological inhibition of Alk activity decrease proliferation
	in vivo inhibition of Alk signaling by virus-mediated shRNA knockdown of Alk and Midkine leads to strongly reduced sympathetic neuron proliferation