| 1 | ALK, ATIC
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| Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report.
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| Tateishi Y, Okudela K, Kawai S, Suzuki T, Umeda S, Matsumura M, Kioi M, Ohashi K.
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| Diagn Pathol 11(1):132.
2016
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| 2 | ALK, MYCN
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| MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells.
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| Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Künkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A.
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| Oncogene 32(8):1059-65. doi: 10.1038/onc.2012.106. Epub 2012 Apr 9.
2013
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| 3 | ALK
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| Identification of ALK germline mutation (3605delG) in pediatric anaplastic medulloblastoma.
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| Coco S, De Mariano M, Valdora F, Servidei T, Ridola V, Andolfo I, Oberthuer A, Tonini GP, Longo L.
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| J Hum Genet 57(10):682-4. doi: 10.1038/jhg.2012.87. Epub 2012 Jul 19.
2012
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| 4 | ALK
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| Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.
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| Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S.
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| Oncogene 31(44):4667-76. doi: 10.1038/onc.2011.616. Epub 2012 Jan 16.
2012
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| 5 | ALK, MYCN
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| Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.
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| Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B.
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| Oncogene 31(50):5193-200. doi: 10.1038/onc.2012.12. Epub 2012 Jan 30.
2012
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| 6 | ALK
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| A novel KIF5B-ALK variant in nonsmall cell lung cancer.
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| Wong DW, Leung EL, Wong SK, Tin VP, Sihoe AD, Cheng LC, Au JS, Chung LP, Wong MP.
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| Cancer ancer. 2011 Jan 10. [Epub ahead of print]PMID: 21225871 2011
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| 7 | ALK
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| EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations.
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| Tiseo M, Gelsomino F, Boggiani D, Bortesi B, Bartolotti M, Bozzetti C, Sammarelli G, Thai E, Ardizzoni A.
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| Lung Cancer 71(2):241-3. Epub 2010 Dec 18.PMID: 21168933 2011
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| 8 | ALK, CLTC, TFE3
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| Clathrin heavy chain gene fusions expressed in human cancers: analysis of cellular functions.
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| Blixt MK, Royle SJ.
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| Traffic 12(6):754-61. doi: 10.1111/j.1600-0854.2011.01183.x. Epub 2011 Mar 24.
2011
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| 9 | ALK
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| Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.
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| Reiff T, Huber L, Kramer M, Delattre O, Janoueix-Lerosey I, Rohrer H.
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| Development. 138(21):4699-708. 2011
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| 10 | ALK, RAP1GDS1
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| Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
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| Schönherr C, Yang HL, Vigny M, Palmer RH, Hallberg B.
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| Oncogene 29(19):2817-30. Epub 2010 Mar 1.PMID: 20190816 2010
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| 11 | ALK
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| Activation of the orphan receptor tyrosine kinase ALK by zinc.
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| Bennasroune A, Mazot P, Boutterin MC, Vigny M.
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| Biochem Biophys Res Commun 398(4):702-6. Epub 2010 Jul 16.
2010
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| 12 | ALK
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| ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time.
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| Gerber DE, Minna JD.
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| Cancer Cell 18(6):548-51. Review.PMID: 21156280 2010
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| 13 | ALK, PHOX2B
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| PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.
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| Bachetti T, Di Paolo D, Di Lascio S, Mirisola V, Brignole C, Bellotti M, Caffa I, Ferraris C, Fiore M, Fornasari D, Chiarle R, Borghini S, Pfeffer U, Ponzoni M, Ceccherini I, Perri P.
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| PLoS One 5(10). pii: e13108.PMID: 20957039 2010
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| 14 | ALK
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| Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.
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| Ardini E, Magnaghi P, Orsini P, Galvani A, Menichincheri M.
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| Cancer Lett 299(2):81-94. Epub 2010 Oct 8. Review.PMID: 20934803 2010
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| 15 | ALK
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| ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer.
|
| Solomon B, Varella-Garcia M, Camidge DR.
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| J Thorac Oncol 4(12):1450-4.
2009
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| 16 | ALK
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| Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4-ALK Fusion Gene.
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| Takahashi T, Sonobe M, Kobayashi M, Yoshizawa A, Menju T, Nakayama E, Mino N, Iwakiri S, Sato K, Miyahara R, Okubo K, Manabe T, Date H.
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| Ann Surg Oncol nn Surg Oncol. 2009 Nov 21. [Epub ahead of print]PMID: 19936840 2009
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| 17 | ALK
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| Inhibition of ALK signaling for cancer therapy.
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| Mossé YP, Wood A, Maris JM.
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| Clin Cancer Res 15(18):5609-14. Epub 2009 Sep 8. Review.PMID: 19737948 2009
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| 18 | ALK, NBL2
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| Oncogenic mutations of ALK kinase in neuroblastoma.
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| Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
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| Nature 455(7215):971-4.
2008
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| 19 | ALK, NBL2
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| Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
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| Janoueix-Lerosey I, Lequin D, Brugières L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, Valteau-Couanet D, Frebourg T, Michon J, Lyonnet S, Amiel J, Delattre O.
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| Nature 455(7215):967-70.
2008
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| 20 | ALK, NBL2
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| Identification of ALK as a major familial neuroblastoma predisposition gene.
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| Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM.
|
| Nature ature. 2008 Aug 24. [Epub ahead of print]
2008
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| 21 | ALK, NBL2
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| Activating mutations in ALK provide a therapeutic target in neuroblastoma.
|
| George RE, Sanda T, Hanna M, Fröhling S, Ii WL, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG, Diller L, Greulich H, Morris SW, Meyerson M, Look AT.
|
| Nature 455(7215):975-8.
2008
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| 22 | ALK, MYCN, NBL2
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| Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.
|
| Stock C, Bozsaky E, Watzinger F, Poetschger U, Orel L, Lion T, Kowalska A, Ambros PF.
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| Am J Pathol 172(1):203-14. Epub 2007 Dec 28. Erratum in: Am J Pathol. 2008 Apr;172(4):1153.
2008
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| 23 | ALK
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| Identification of ALK as a major familial neuroblastoma predisposition gene.
|
| Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM.
|
| Nature 455(7215):930-5. Epub 2008 Aug 24. 2008
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| 24 | ALK, PHOX2B
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| Janoueix-Lerosey I, Lequin D, Brugières L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, Valteau-Couanet D, Frebourg T, Michon J, Lyonnet S, Amiel J, Delattre O.
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| Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
|
| Nature 455(7215):967-70.
2008
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| 25 | ALK
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| Zhang J, Lu Y, Yuan Y, Zhang X, Geng J, Chen Y, Cloutier S, McVetty PB, Li G.
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| Map-based cloning and characterization of a gene controlling hairiness and seed coat color traits in Brassica rapa.
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| Plant Mol Biol lant Mol Biol. 2008 Nov 28. [Epub ahead of print]
2008
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| 26 | ALK
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| Suresh CH, Mohan N, Vijayalakshmi KP, George R, Mathew JM.
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| Typical aromatic noncovalent interactions in proteins: A theoretical study using phenylalanine.
|
| J Comput Chem Comput Chem. 2008 Nov 25. [Epub ahead of print]
2008
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| 27 | EML4, ALK
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| Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
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| Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H.
|
| Nature 448(7153):561-6. Epub 2007 Jul 11. 2007
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| 28 | ALK
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| Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
|
| Perez-Pinera P, Zhang W, Chang Y, Vega JA, Deuel TF.
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| J Biol Chem. 282(39):28683-90. 2007
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| 29 | ALK, IMT, SEC31A
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| Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.
|
| Panagopoulos I, Nilsson T, Domanski HA, Isaksson M, Lindblom P, Mertens F, Mandahl N.
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| Int J Cancer 118(5):1181-6. 2006
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| 30 | STAT3, ALK, NPM1
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| Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
|
| Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, Karras JG, Levy DE, Inghirami G.
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| Nat Med 11(6):623-629. Epub 2005 May 15. 2005
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| 31 | ALK, RANBP2
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| Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.
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| Ma Z, Hill DA, Collins MH, Morris SW, Sumegi J, Zhou M, Zuppan C, Bridge JA.
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| Genes Chromosomes Cancer 37(1):98-105. 2003
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| 32 | ALK, ATIC, CLTC, MSN, MYH9, RNF213, TFG, TPM3, TPM4
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| Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.
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| Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E.
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| Genes Chromosomes Cancer 37(4):427-32. 2003
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| 33 | ALK, CLTC
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| ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases.
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| Gascoyne RD, Lamant L, Martin-Subero JI, Lestou VS, Harris NL, Müller-Hermelink HK, Seymour JF, Campbell LJ, Horsman DE, Auvigne I, Espinos E, Siebert R, Delsol G.
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| Blood 102(7):2568-73. Epub 2003 May 22.
2003
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| 34 | ALK, SHC3
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| Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.
|
| Miyake I, Hakomori Y, Shinohara A, Gamou T, Saito M, Iwamatsu A, Sakai R.
|
| Oncogene 21(38):5823-34. 2002
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| 35 | ALCL, ALK, CARS, IMT, RNF213
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| Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.
|
| Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, De Wolf-Peeters C, Pauwels P, Hagemeijer A, Marynen P.
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| Genes Chromosomes Cancer 34(4):354-62. 2002
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| 36 | ALK
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| Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death.
|
| Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, Levy DE, Inghirami G.
|
| Oncogene. 21(7):1038-47. 2002
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| 37 | ALK
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| Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
|
| Stoica GE, Kuo A, Powers C, Bowden ET, Sale EB, Riegel AT, Wellstein A.
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| J Biol Chem. 277(39):35990-8. 2002
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| 38 | ALK
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| Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
|
| Stoica GE, Kuo A, Aigner A, Sunitha I, Souttou B, Malerczyk C, Caughey DJ, Wen D, Karavanov A, Riegel AT, Wellstein A.
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| J Biol Chem. 76(20):16772-9. 2001
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| 39 | ALK, ATIC
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| ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
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| Colleoni GW, Bridge JA, Garicochea B, Liu J, Filippa DA, Ladanyi M.
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| Am J Pathol 156(3):781-9. 2000
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| 40 | ALK
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| Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like).
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| Touriol C, Greenland C, Lamant L, Pulford K, Bernard F, Rousset T, Mason DY, Delsol G.
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| Blood 95(10):3204-7. 2000
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| 41 | IMT, ALK
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| Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
|
| Griffin CA, et al.
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| Cancer Res 59(12):2776-80. 1999
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| 42 | ALK, PML, RARA
|
| Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21.
|
| Melnick A, Fruchtman S, Zelent A, Liu M, Huang Q, Boczkowska B, Calasanz M, Fernandez A, Licht JD, Najfeld V.
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| Leukemia 13(10):1534-8. 1999
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| 43 | ALK
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| The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation.
|
| Hübinger G, Scheffrahn I, Müller E, Bai R, Duyster J, Morris SW, Schrezenmeier H, Bergmann L.
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| Exp Hematol. 27(12):1796-805. 1999
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| 44 | ALK, NPM1
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| A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation.
|
| Ott G, Bastian BC, Katzenberger T, Decoteau JF, Kalla J, Rosenwald A, Weissinger F, Ott MM, Kadin ME, Muller-Hermelink HK.
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| Br J Haematol 100(1):187-90. 1998
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| 45 | ALK
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| Chromosomal abnormalities in nodal and extranodal CD30+ anaplastic large cell lymphomas : infrequent detection of the t(2;5) in extranodal lymphomas.
|
| Ott G, et al.
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| Genes Chromosomes Cancer 22 : 114-121. 1998
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| 46 | ALK, MLF1, NPM1
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| Non-Hodgkin's lymphomas and myeloid disorders : deletions associated with t(2;5) and t(3;5) detected by FISH.
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| Dragon-Durey MA, Goguel AF, Leonard C, Berger R, Bressac-de-Paillerets B, Fauvet D, Bernheim A.
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| Leukemia 12 : 1159-1162. 1998
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| 47 | ALK
|
| The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma.
|
| Wlodarska I, et al.
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| Blood 92 : 2688-2695. 1998
|
| 48 | ALK, NPM1
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| Detection of the t(2;5)-associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals.
|
| Trumper L, et al.
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| Br J Haematol 103(4):1138-44. 1998
|
| 49 | ALK
|
| Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
|
| Iwahara TG, et al.
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| Oncogene 14 : 439-449. 1997
|
| 50 | ALK, NPM1
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| Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization.
|
| Mathew P, et al.
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| Blood 89 : 1678-1685. 1997
|
| 51 | ALK
|
| ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).
|
| Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP.
|
| Oncogene 14(18):2175-88. 1997
|
| 52 | ALK, NPM1
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| NPM-ALK gene fusion and Hodgkin's disease.
|
| Waggott W, Delsol G, Jarret RF, Mason DY, Gatter KC, Boultwood J, Wainscoat JS.
|
| Blood 90(4):1712-3. No abstract available. 1997
|
| 53 | ALK, NPM1
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| Molecular characterization of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease.
|
| Yee HT, et al.
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| Blood 87 : 1081-1088. 1996
|
| 54 | ALK, NPM1
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| Occurrence of the t(2;5)(p23;q35) in Non-Hodgkin's lymphoma.
|
| Weisenburger DD, et al.
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| Blood 87 : 3860-3868. 1996
|
| 55 | ALK, NPM1
|
| Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease : indication of a common pathogenesis ?
|
| Orscheschek K, et al.
|
| Lancet 345 : 87-90. 1995
|
| 56 | ALK, NPM1
|
| Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease.
|
| Wellmann A, et al.
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| Blood 86 : 2321-2328. 1995
|
| 57 | ALK, NPM1
|
| Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in Non-Hodgkin's lymphoma.
|
| Morris SW, et al.
|
| Science 263 : 1281-1284. 1994
|
| 58 | NPM1, ALK
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| Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas.
|
| Bullrich F, et al.
|
| Cancer Res 54 : 2873-2877. 1994
|