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FLASH GENE

Symbol

MAGT1

contributors: mct/npt/pgu - updated : 12-10-2017

HGNC name	magnesium transporter 1
HGNC id	28880

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRX95 mental retardation, X-linked 95 XMEN immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia
Location	Xq21.1      Physical location : 77.081.863 - 77.151.065
Synonym name	implantation-associated protein
	oligosaccharyltransferase 3B
Synonym symbol(s)	FLJ14726, IAP, MGC64926, OST3B, PRO0756, bA217H1.1, DKFZp564K142, IAG2, IAP, MRX95, XMEN

DNA

TYPE	functioning gene
STRUCTURE	69.20 kb     10 Exon(s)

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032121 10 - 4035 38 335 - 2005 15804357

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Endocrine adrenal gland       highly Lymphoid/Immune thymus       highly Nervous brain         Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

lumenally oriented active site CVVC motif in MAGT1 is required for glycosylation of STT3B-dependent acceptor sites including those that are closely bracketed by disulfides or contain cysteine as the internal residue

HOMOLOGY

interspecies

ortholog to yeast Ost6

Homologene

FAMILY

OST3/OST6 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	is at the plasma membrane, but the N terminus is extracellular

basic FUNCTION	catalyzes the cotranslational transfer of high-mannose sugars to nascent polypeptides during N-linked glycosylation in the rough endoplasmic reticulum lumen
	may provide a selective and regulated pathway for Mg2+ transport in epithelial cells
	required for cellular Mg2+ uptake
	play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
	MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
	signaling role for MAGT1 has been proven in T lymphocytes, where Mg(2+) functions as a second messenger, coupling TCR activation to intracellular effectors
	Mg and MAGT1 play an important role in osteogenic differentiation and may be likely involved in the bone regeneration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MAGT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST)

INTERACTION

DNA

RNA

small molecule

protein

partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRX95 , XMEN

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	expression levels of MAGT1 in Hepatocellular carcinoma (HCC) may be potential biomarkers for the diagnosis and prognosis of this cancer
Therapy target

ANIMAL & CELL MODELS