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FLASH GENE
Symbol CENPL contributors: mct - updated : 30-01-2008
HGNC name centromere protein L
HGNC id 17879
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with
    • the CENPA-NAC complex
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, APITD1, ITGB3BP
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1QM
    Susceptibility
    Variant & Polymorphism
    Candidate gene for growth retardation in del 1q24q25 microdeletion syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS