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FLASH GENE
Symbol CENPL contributors: mct - updated : 30-01-2008
HGNC name centromere protein L
HGNC id 17879
Corresponding disease
DEL1QM chromosome 1q interstitial deletions
Location 1q25.1      Physical location : 173.768.690 - 173.793.777
Synonym symbol(s) C1orf155, CENP-L, FLJ31044, FLJ31786, RP3-383J4.1
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1910 - 344 - Izuta (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineparathyroid    
Reproductivefemale systemuteruscervix  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with
  • the CENPA-NAC complex
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, APITD1, ITGB3BP
  • constitutive centromere-associated network (CCAN) component (Hori 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1QM
    Susceptibility
    Variant & Polymorphism
    Candidate gene for growth retardation in del 1q24q25 microdeletion syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS