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FLASH GENE
Symbol INSC contributors: mlc/np - updated : 03-01-2008
HGNC name inscuteable homolog (Drosophila)
HGNC id 33116
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Endocrineparathyroid    
Hearing/Equilibriumear    
Urinarykidney    
Visualeye    
cell lineage
cell lines parathyroid tumor, chondrosarcoma, epidermoid carcinoma, and skin tumor
fluid/secretion
at STAGE
Text cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • central INSC homologous (ISH) domain
  • C-terminus containing 4 putative armadillo repeats and a PDZ-binding motif
    • HOMOLOGY
    interspecies homolog to C-Elegans F43E2.3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as an adaptor protein to tether GPSM2 with PARD3B
  • implicated in the apical-basal orientation of mitotic spindle and the basal localization of Prospero (PROX1, PROX2) and NUMB
  • might be implicated in asymmetrical cell division of neural stem cells and other stem cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS