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FLASH GENE
Symbol INSC contributors: mlc/np - updated : 03-01-2008
HGNC name inscuteable homolog (Drosophila)
HGNC id 33116
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • central INSC homologous (ISH) domain
  • C-terminus containing 4 putative armadillo repeats and a PDZ-binding motif
  • HOMOLOGY
    interspecies homolog to C-Elegans F43E2.3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as an adaptor protein to tether GPSM2 with PARD3B
  • implicated in the apical-basal orientation of mitotic spindle and the basal localization of Prospero (PROX1, PROX2) and NUMB
  • might be implicated in asymmetrical cell division of neural stem cells and other stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS