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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

INSC

contributors: mlc/np - updated : 03-01-2008

HGNC name	inscuteable homolog (Drosophila)
HGNC id	33116

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 13 - 2970 63.5 579 - Izaki (2006) variant 2 - - 2894 - 532 - Izaki (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland         Endocrine parathyroid         Hearing/Equilibrium ear         Urinary kidney         Visual eye

cell lineage
cell lines	parathyroid tumor, chondrosarcoma, epidermoid carcinoma, and skin tumor
fluid/secretion

at STAGE

Text

cochlea

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	central INSC homologous (ISH) domain
	C-terminus containing 4 putative armadillo repeats and a PDZ-binding motif

HOMOLOGY

interspecies

homolog to C-Elegans F43E2.3

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	functioning as an adaptor protein to tether GPSM2 with PARD3B
	implicated in the apical-basal orientation of mitotic spindle and the basal localization of Prospero (PROX1, PROX2) and NUMB
	might be implicated in asymmetrical cell division of neural stem cells and other stem cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS