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FLASH GENE
Symbol INSC contributors: mlc/np - updated : 03-01-2008
HGNC name inscuteable homolog (Drosophila)
HGNC id 33116
Location 11p15.2      Physical location : 15.133.969 - 15.268.752
Synonym name
  • inscuteable
  • DNA
    TYPE functioning gene
    STRUCTURE 96.00 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2970 63.5 579 - Izaki (2006)
    - - 2894 - 532 - Izaki (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Endocrineparathyroid    
    Hearing/Equilibriumear    
    Urinarykidney    
    Visualeye    
    cell lineage
    cell lines parathyroid tumor, chondrosarcoma, epidermoid carcinoma, and skin tumor
    fluid/secretion
    at STAGE
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • central INSC homologous (ISH) domain
  • C-terminus containing 4 putative armadillo repeats and a PDZ-binding motif
  • HOMOLOGY
    interspecies homolog to C-Elegans F43E2.3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as an adaptor protein to tether GPSM2 with PARD3B
  • implicated in the apical-basal orientation of mitotic spindle and the basal localization of Prospero (PROX1, PROX2) and NUMB
  • might be implicated in asymmetrical cell division of neural stem cells and other stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS