basic FUNCTION
| functioning as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration |
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activating phospholipase C |
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possibility of involvement of CASR in pathophysiology of epileptic disorders |
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putatively involved in the regulation of insulin release |
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can regulate parathyroid hormone gene expression in heterologous cells |
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regulates extracellular calcium ion homeostasis by controlling the rate of parathyroid hormone secretion from the parathyroid gland and the rate of calcium re-absorption by the kidney |
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plays an integral role in calcium homeostasis and the regulation of other cellular functions including cell proliferation and cytoskeletal organisation |
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key role for CASR-induced phospholipase C activation and the release of intracellular calcium |
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in adipocytes may be involved in the pathogenesis of obesity by promoting adipocyte differentiation and adipogenesis |
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key role in normal epidermal development |
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specifically modulates nuclear Ca(2+) signalling through the IP3 receptors pathway |
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essential role in systemic calcium homeostasis through its ability to sense small changes in circulating calcium concentration and to couple this information to intracellular signaling pathways that influence parathyroid hormone secretion |
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role in other cellular functions including the control of cellular proliferation, differentiation and apoptosis |
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contributes to maintain homeostatic levels of extracellular calcium |
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controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis |
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CASR and GPR68 reciprocally inhibit signaling through each other in central neurons, but strong intracellular acidification impairs CASR function, and potentiates GPR68 function |
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is an important component in the mechanism of bone metastasis in renal cell carcinoma (RCC) |
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importance of CASR in the regulation of vascular tone and blood pressure |
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G protein-coupled receptor that plays a key role in calcium homeostasis, by sensing free calcium levels in blood and regulating parathyroid hormone secretion in response |