Citations for
1CASR, GPR68
Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.
Wei WC, Jacobs B, Becker EB, Glitsch MD.
Proc Natl Acad Sci U S A 112(34):10738-43. doi: 10.1073/pnas.1506085112. 2015
2CASR, GPR39
The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia.
Asraf H, Salomon S, Nevo A, Sekler I, Mayer D, Hershfinkel M.
J Cell Physiol 229(7):868-77. doi: 10.1002/jcp.24514. 2014
3CASR
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions.
Diez-Fraile A, Lammens T, Benoit Y, D'Herde KG.
Curr Mol Med 13(2):282-95. Review. 2013
4CASR
The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis.
Casalà C, Gil-Guiñón E, Ordóñez JL, Miguel-Queralt S, Rodríguez E, Galván P, Lavarino C, Munell F, de Alava E, Mora J, de Torres C.
Carcinogenesis 34(2):268-76. doi: 10.1093/carcin/bgs338. Epub 2012 Oct 29. 2013
5CASR
Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.
Leach K, Wen A, Davey AE, Sexton PM, Conigrave AD, Christopoulos A.
Endocrinology 153(9):4304-16. doi: 10.1210/en.2012-1449. Epub 2012 Jul 13. 2012
6CASR, HYPOCA
CASR gene activating mutations in two families with autosomal dominant hypocalcemia.
Guarnieri V, Valentina D'Elia A, Baorda F, Pazienza V, Benegiamo G, Stanziale P, Copetti M, Battista C, Grimaldi F, Damante G, Pellegrini F, D'Agruma L, Zelante L, Carella M, Scillitani A.
Mol Genet Metab 107(3):548-52. doi: 10.1016/j.ymgme.2012.06.012. Epub 2012 Jun 26. 2012
7CASR
Calcium sensing receptor regulates cardiomyocyte function through nuclear calcium.
Zhong X, Liu J, Lu F, Wang Y, Zhao Y, Dong S, Leng X, Jia J, Ren H, Xu C, Zhang W.
Cell Biol Int 36(10):937-43. doi: 10.1042/CBI20110594. 2012
8CASR
Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.
Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD.
J Invest Dermatol 132(10):2350-9. doi: 10.1038/jid.2012.159. Epub 2012 May 24. 2012
9CASR
Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue.
Cifuentes M, Fuentes C, Tobar N, Acevedo I, Villalobos E, Hugo E, Ben-Jonathan N, Reyes M.
Mol Cell Endocrinol 361(1-2):24-30. doi: 10.1016/j.mce.2012.03.006. Epub 2012 Mar 16. 2012
10CASR
Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level.
Zhuang X, Northup JK, Ray K.
J Biol Chem 287(6):4165-76. doi: 10.1074/jbc.M111.271528. Epub 2011 Dec 12. 2012
11CASR
The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARγ pathway.
He YH, He Y, Liao XL, Niu YC, Wang G, Zhao C, Wang L, Tian MJ, Li Y, Sun CH.
Mol Cell Biochem 361(1-2):321-8. doi: 10.1007/s11010-011-1118-5. Epub 2011 Oct 25. 2012
12CASP1, CASR, NLRP3
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ.
Nature 492(7427):123-7. doi: 10.1038/nature11588. Epub 2012 Nov 11. 2012
13CASR, TES
Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling.
Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK.
Biochem Biophys Res Commun 412(4):584-9. Epub 2011 Aug 6. 2011
14CASR
Calcium-sensing receptor and calcium kidney stones.
Vezzoli G, Terranegra A, Rainone F, Arcidiacono T, Cozzolino M, Aloia A, Dogliotti E, Cusi D, Soldati L.
J Transl Med 9:201. doi: 10.1186/1479-5876-9-201. Review. 2011
15CASR
Calcium-sensing receptor modulates cell adhesion and migration via integrins.
Tharmalingam S, Daulat AM, Antflick JE, Ahmed SM, Nemeth EF, Angers S, Conigrave AD, Hampson DR.
J Biol Chem 286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3. 2011
16CASR, SAR1A
Sar1-dependent trafficking of the human calcium receptor to the cell surface.
Zhuang X, Chowdhury S, Northup JK, Ray K.
Biochem Biophys Res Commun 396(4):874-80. Epub 2010 May 10. 2010
17CASR, HYPOCA
Calcium-sensing Receptor (CASR) Mutations and Denaturing High Performance Liquid Chromatography (DHPLC).
Cole D, Yun F, Wong B, Shuen A, Booth R, Scillitani A, Pidasheva S, Zhou X, Canaff L, Hendy G.
J Mol Endocrinol Mol Endocrinol. 2009 Jan 29. [Epub ahead of print] 2009
18CASR, FIHP, GCM2
Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism.
Canaff L, Zhou X, Mosesova I, Cole DE, Hendy GN.
Hum Mutat 30(1):85-92. 2009
19CASR, HHC1
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia.
Lietman SA, Tenenbaum-Rakover Y, Jap TS, Yi-Chi W, De-Ming Y, Ding C, Kussiny N, Levine MA.
J Clin Endocrinol Metab 94(11):4372-9. Epub 2009 Sep 29.PMID: 19789209 2009
20CASR
The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells.
Galitzer H, Lavi-Moshayoff V, Nechama M, Meir T, Silver J, Naveh-Many T.
BMC Biol 7:17.PMID: 19397786 2009
21CASR
Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor.
Saidak Z, Boudot C, Abdoune R, Petit L, Brazier M, Mentaverri R, Kamel S.
Exp Cell Res 315(12):2072-80. Epub 2009 Mar 13.PMID: 19285978 2009
22CASR
The role of the calcium-sensing receptor in the development and progression of cancer.
Saidak Z, Mentaverri R, Brown EM.
Endocr Rev 30(2):178-95. Epub 2009 Feb 23. Review.PMID: 19237714 2009
23CASR, TRPV5
Activation of the Ca2+-sensing receptor stimulates the activity of the epithelial Ca2+ channel TRPV5.
Topala CN, Schoeber JP, Searchfield LE, Riccardi D, Hoenderop JG, Bindels RJ.
Cell Calcium 45(4):331-9. Epub 2009 Jan 20.PMID: 19157541 2009
24CASR, KCNJ1, NR3C2, SCNN1G, SNN1B
Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population.
Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ.
Hypertension 51(6):1658-64. Epub 2008 Apr 28. 2008
25CASR, EIG8
An idiopathic epilepsy syndrome linked to 3q13.3-q21 and missense mutations in the extracellular calcium sensing receptor gene.
Kapoor A, Satishchandra P, Ratnapriya R, Reddy R, Kadandale J, Shankar SK, Anand A.
Ann Neurol 64(2):158-67. 2008
26CASR,HHC1
Identification and functional characterization of a novel mutation in the calcium-sensing receptor gene in familial hypocalciuric hypercalcemia: modulation of clinical severity by vitamin D status.
Zajickova K, Vrbikova J, Canaff L, Pawelek PD, Goltzman D, Hendy GN.
J Clin Endocrinol Metab 92(7):2616-23. Epub 2007 May 1. 2007
27HHC1, CASR
Molecular genetic analysis of the calcium sensing receptor gene in patients clinically suspected to have familial hypocalciuric hypercalcemia: phenotypic variation and mutation spectrum in a danish population.
Nissen PH, Christensen SE, Heickendorff L, Brixen K, Mosekilde L.
J Clin Endocrinol Metab 92(11):4373-9. Epub 2007 Aug 14. 2007
28CASR, KCNJ10, KCNJ15
Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.
Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT.
Am J Physiol Renal Physiol 292(3):F1073-81. Epub 2006 Nov 22. 2007
29NSHPT, CASR, HHC1
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.
Pidasheva S, Grant M, Canaff L, Ercan O, Kumar U, Hendy GN.
Hum Mol Genet 15(14):2200-9. Epub 2006 Jun 1. 2006
30STAMBP, CASR
AMSH regulates calcium-sensing receptor signaling through direct interactions.
Herrera-Vigenor F, Hernandez-Garcia R, Valadez-Sanchez M, Vazquez-Prado J, Reyes-Cruz G.
Biochem Biophys Res Commun 347(4):924-30. Epub 2006 Jul 7. 2006
31CASR, HYPOCA, HYPOCAB
Hypocalciuric hypercalcemia presenting as neonatal rib fractures: a newly described mutation of the calcium-sensing receptor gene.
Nyweide K, Feldman KW, Gunther DF, Done S, Lewis C, Van Eenwyk C.
Pediatr Emerg Care 22(11):722-4. 2006
32CASR
Biophysical properties of the extra-cellular domain of the calcium-sensing receptor.
Ryan ZC, Craig TA, Venyaminov SY, Thompson JR, Kumar R.
Biochem Biophys Res Commun 349(1):339-44. Epub 2006 Aug 17. 2006
33SPINK1, CASR
Mutations in the calcium-sensing receptor: a new genetic risk factor for chronic pancreatitis?
Felderbauer P, Klein W, Bulut K, Ansorge N, Dekomien G, Werner I, Epplen JT, Schmitz F, Schmidt WE.
Scand J Gastroenterol 41(3):343-8. 2006
34CASR, HHC1
Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia.
Ward BK, Magno AL, Blitvich BJ, Rea AJ, Stuckey BG, Walsh JP, Ratajczak T.
Clin Endocrinol (Oxf) 64(5):580-7. 2006
35NSHPT, HHC1, CASR
Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia.
Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN.
Hum Mol Genet 14(12):1679-90. Epub 2005 May 6. 2005
36CASR, NSHPT, HHC1
Functional characterization of calcium-sensing receptor codon 227 mutations presenting as either familial (benign) hypocalciuric hypercalcemia or neonatal hyperparathyroidism.
Wystrychowski A, Pidasheva S, Canaff L, Chudek J, Kokot F, Wiecek A, Hendy GN.
J Clin Endocrinol Metab 90(2):864-70. Epub 2004 Nov 30. 2005
37HYPOCA, CASR
A family with autosomal dominant hypocalcaemia with hypercalciuria (ADHH): mutational analysis, phenotypic variability and treatment challenges.
Burren CP, Curley A, Christie P, Rodda CP, Thakker RV.
J Pediatr Endocrinol Metab 18(7):689-99. 2005
38CASR, HPT2
A novel gain-of-function mutation (F821L) in the transmembrane domain of calcium-sensing receptor is a cause of severe sporadic hypoparathyroidism.
Shiohara M, Mori T, Mei B, Brown EM, Watanabe T, Yasuda T.
Eur J Pediatr 163(2):94-8. Epub 2003 Dec 16. 2004
39PTH, CASR, HYPOCA
A novel mutation in the calcium-sensing receptor responsible for autosomal dominant hypocalcemia in a family with two uncommon parathyroid hormone polymorphisms.
Alvarez-Hernandez D, Santamaria I, Rodriguez-Garcia M, Iglesias P, Delgado-Lillo R, Cannata-Andia JB.
J Mol Endocrinol 31(2):255-62. 2003
40NSHPT, CASR
Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia.
D'Souza-Li L, Yang B, Canaff L, Bai M, Hanley DA, Bastepe M, Salisbury SR, Brown EM, Cole DE, Hendy GN.
J Clin Endocrinol Metab 87(3):1309-18. 2002
41CASR, HYPOCA
Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain.
Hu J, Mora S, Colussi G, Proverbio MC, Jones KA, Bolzoni L, De Ferrari ME, Civati G, Spiegel AM.
J Bone Miner Res 17(8):1461-9. 2002
42HYPOCAB, CASR
Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome.
Vargas-Poussou R, Huang C, Hulin P, Houillier P, Jeunemaitre X, Paillard M, Planelles G, Dechaux M, Miller RT, Antignac C.
J Am Soc Nephrol 13(9):2259-66. 2002
43CASR, HYPOCAB
Association between activating mutations of calcium-sensing receptor and Bartter's syndrome.
Watanabe S, Fukumoto S, Chang H, Takeuchi Y, Hasegawa Y, Okazaki R, Chikatsu N, Fujita T.
Lancet 360(9334):692-4. 2002
44CASR
Association between Total Serum Calcium and the A986S Polymorphism of the Calcium-Sensing Receptor Gene.
Cole DE, Vieth R, Trang HM, Wong BY, Hendy GN, Rubin LA.
Mol Genet Metab 72(2):168-74. 2001
45CASR
An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
D'Souza-Li L, Canaff L, Janicic N, Cole DE, Hendy GN.
Hum Mutat 18(5):411-21. 2001
46CASR
Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas.
Chikatsu N, Fukumoto S, Takeuchi Y, Suzawa M, Obara T, Matsumoto T, Fujita T.
J Biol Chem 275(11):7553-7. 2000
47CASR, HHC1, HYPOCA, NSHPT
Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.
Hendy GN, D'Souza-Li L, Yang B, Canaff L, Cole DE.
Hum Mutat 16(4):281-96. 2000
48CASR, HHC1
Three novel activating mutations in the calcium-sensing receptor responsible for autosomal dominant hypocalcemia
Conley YP, Finegold DN, Peters DG, Cook JS, Oppenheim DS, Ferrell RE.
Mol Genet Metab 71(4):591-8. 2000
49CASR, HYPOCA
A large homozygous or heterozygous in-frame deletion within the calcium-sensing receptor's carboxylterminal cytoplasmic tail that causes autosomal dominant hypocalcemia.
Lienhardt A, Garabedian M, Bai M, Sinding C, Zhang Z, Lagarde JP, Boulesteix J, Rigaud M, Brown EM, Kottler ML.
J Clin Endocrinol Metab 85(4):1695-702. 2000
50CASR, HYPOCA
A novel activating mutation in calcium-sensing receptor gene associated with a family of autosomal dominant hypocalcemia.
Okazaki R, et al.
J Clin Endocrinol Metab 84(1):363-6. 1999
51CASR
The G-Protein-Coupled, Extracellular Ca(2+)-Sensing Receptor: Expression in Pancreatic Islet B-Cells and Possible Role in the Regulation of Insulin Release.
Rasschaert J, et al.
Mol Genet Metab 68(2):328-331. No abstract available 1999
52CASR, NSHPT
Familial hypoparathyroidism : identification of a novel gain of function mutation in transmembrane domain 5 of the calcium-sensing receptor.
Watanabe T, et al.
J Clin Endocrinol Metab 83 : 2497-2502. 1998
53CASR
Activating mutations of the Ca2+-sensing receptor.
Mancilla EE, De Luca F, Baron J.
Mol Genet Metab 64 : 198-204. 1998
54CASR, NSHPT
Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism.
Kobayashi M, Tanaka H, Tsuzuki K, Tsuyuki M, Igaki H, Ichinose Y, Aya K, Nishioka N, Seino Y.
J Clin Endocrinol Metab 82(8):2716-9. 1997
55CASR, HHC1
A novel mutation (L174R) in the Ca2+-sensing receptor gene associated with familial hypocalciuric hypercalcemia.
Ward BK, Stuckey BG, Gutteridge DH, Laing NG, Pullan PT, Ratajczak T.
Hum Mutat 10(3):233-5. No abstract available. 1997
56CASR, HPT2
A Ca(2+)-sensing receptor mutation causes hypoparathyroidism by increasing receptor sensitivity to Ca2+ and maximal signal transduction.
Mancilla EE, De Luca F, Ray K, Winer KK, Fan GF, Baron J.
Pediatr Res 42(4):443-7. 1997
57HPT2, CASR
Mutations in the Ca2+-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism.
Baron J, et al.
Hum Mol Genet 5 : 601-606. 1996
58HPT2, CASR
The Ca2+-sensing receptor gene (PCAR1) mutation T151M in isolated autosomal dominant hypoparathyroidism.
Lšvlie R, et al.
Hum Genet 98 : 129-133. 1996
59HHC1, HYPOCA, NSHPT, CASR
Expression and characterization of inactivating and activating mutations in the human Ca2+ o-sensing receptor.
Bai M, et al.
J Biol Chem 271 : 19537-19545. 1996
60HYPOCA, CASR
A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor.
Pearce SHS, et al.
N Engl J Med 335 : 1115-1122. 1996
61HHC1, CASR
Familial hypocalciuric hypercalcemia associated with mutation in the human Ca2+ sensing receptor gene.
Aida K, et al.
J Clin Endocrinol Metab 80 : 2594-2598. 1995
62CASR, HHC1, NSHPT
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Ho C, et al.
Nat Genet 11 : 389-394. 1995
63CASR
Mapping of the calcium-sensing receptor gene (CASR) to human chromosome 3q13.3-21 by fluorescence in situ hybridization and localization to rat chromosome 11 and mouse chromosome 16.
Janicic N, et al.
Mamm Genome 6 : 798-801. 1995
64TSG3D, CASR
Genetic abnormalities in sporadic parathyroid adenomas : loss of heterozygosity for chromosome 3q markers flanking the calcium receptor locus.
Thompson DB, et al.
J Clin Endocrinol Metab 80 : 3377-3380. 1995
65CASR, NSHPT
Insertion of an alu sequence in the Ca2+-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Janicic N, et al.
Am J Hum Genet 56 : 880-886. 1995
66CASR, HHC1
Familial hypocalciuric hypercalcemia associated with mutation in the human Ca(2+)-sensing receptor gene.
Aida K, Koishi S, Inoue M, Nakazato M, Tawata M, Onaya T.
J Clin Endocrinol Metab 80(9):2594-8.PMID: 7673400 1995
67CASR, HHC1, NSHPT
Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Pollak MR, et al.
J Clin Invest 93 : 1108-1112. 1994
68HYPOCA, CASR
Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation.
Pollak MR, et al.
Nat Genet 8 : 303-307. 1994
69CASR, HHC1, NSHPT
Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Pollak MR, et al.
Cell 75 : 1297-1303. 1993