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FLASH GENE
Symbol ATP1A2 contributors: npt/mct - updated : 21-02-2020
HGNC name ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide
HGNC id 800
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • E1-E2 ATPase
  • haloacid dehalogenase-like hydrolase domain
  • cation transporting ATPase, C-terminus domain
    • HOMOLOGY
    interspecies homolog to murine Atp1a2
    intraspecies paralog to ATP1A1, ATP1A3
    Homologene
    FAMILY
  • cation transport ATPase (P-type) family
  • subfamily of Na+/K+ -ATPases
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • osmotic balance and cell volume stability
  • catalyzing the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1B2 and maybe others
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • binding to ATP1B2
  • GPNMB promotes glioma growth via ATP1A1, ATP1A2, ATP1A3, ATP1A4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MHP2 , AHPC , DEE98 , FARIMPD
    Susceptibility to bipolar disorders
    Variant & Polymorphism SNP increasing the risk of bipolar disorders (Goldstein 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS