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GENATLAS PHENOTYPE
last update : 29-05-2024
Symbol MHP2
Location 1q23.2
Name migraine familial hemiplegic, 2
Other name(s) migraine familial basilar
Corresponding gene ATP1A2
Other symbol(s) FHM2, AHC
Main clinical features migraine with aura, associated with hemiparesis during the aura, with epileptic seizures during severe migraine attacks in some patients
Genetic determination autosomal dominant
Related entries including forms with episodes of both very severe and transient neurological symptoms that were triggered by mild head trauma as well as permanent mental retardation
Function/system disorder neurology
Type disease
Mechanism(s)
Gene mutationChromosome rearrangementEffectComments
missense   other protein functional but kinetically altered
Remark(s)
Genotype/Phenotype correlations Gly900Arg mutation present in a family with epilepsy and familial hemiplegic migraine (Deprez 2008)