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FLASH GENE
Symbol INSM1 contributors: mct/npt - updated : 13-05-2009
HGNC name insulinoma-associated 1
HGNC id 6090
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text situated on the promoter region of the NEUROD1 gene
STRUCTURE 2.83 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
motif repetitive sequence
text structure three putative E-boxes (approximately 361 bp) upstream of the transcription start site was sufficient to confer tissue-specific transcriptional activity
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2838 53 510 - Liu (2006)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Nervousbrain   moderately
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines insulinoma and other neuroendocrine tumor cell lines, small cells lung cancer
fluid/secretion
at STAGE
physiological period fetal
Text exclusively expressed in the foetal pancreas and nervous system, and in tumours of neuroendocrine origin
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SNAG motif (repressor motif), proline-rich portion of required for cyclin D1 (CCND1) binding (Zhang 2009)
  • three proline-rich domain
  • a zinc finger DNA-binding domain and a putative prohormone domain
  • five zinc finger protein, class I (Cys2-His2) at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • SNAG transcriptional repressor family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • recruits cyclin D1 (CCND1) and HDACs, which confer transcriptional repressor activity
  • may be auto-regulated and play a role in pancreas and neuronal development
  • zinc finger transcription factor that plays an important role in pancreatic beta-cell development (Zhang 2009)
  • functions as a transcriptional repressor of the NEUROD1 gene through the recruitment of cyclin D1 and histone deacetylases specifically in the regulation of the NEUROD1 gene
  • binds to cyclin D1, interrupts cell cycle signaling, and inhibits cellular proliferation (Zhang 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SORBS1
  • recruits cyclin D1 and HDACs, which confer transcriptional repressor activity
  • interacting with CCND1 (binding to cyclin D1 could inhibit the CDK4 activity) (Zhang 2009)
  • novel HH target
  • cell & other
    REGULATION
    activated by NEUROD1 transcription through the proximal E-box element of the INSM1 promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker for neuroendocrine differentiation in human lung tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS