Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol INSM1 contributors: mct/npt - updated : 13-05-2009
HGNC name insulinoma-associated 1
HGNC id 6090
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal SNAG motif (repressor motif), proline-rich portion of required for cyclin D1 (CCND1) binding (Zhang 2009)
  • three proline-rich domain
  • a zinc finger DNA-binding domain and a putative prohormone domain
  • five zinc finger protein, class I (Cys2-His2) at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • SNAG transcriptional repressor family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • recruits cyclin D1 (CCND1) and HDACs, which confer transcriptional repressor activity
  • may be auto-regulated and play a role in pancreas and neuronal development
  • zinc finger transcription factor that plays an important role in pancreatic beta-cell development (Zhang 2009)
  • functions as a transcriptional repressor of the NEUROD1 gene through the recruitment of cyclin D1 and histone deacetylases specifically in the regulation of the NEUROD1 gene
  • binds to cyclin D1, interrupts cell cycle signaling, and inhibits cellular proliferation (Zhang 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SORBS1
  • recruits cyclin D1 and HDACs, which confer transcriptional repressor activity
  • interacting with CCND1 (binding to cyclin D1 could inhibit the CDK4 activity) (Zhang 2009)
  • novel HH target
  • cell & other
    REGULATION
    activated by NEUROD1 transcription through the proximal E-box element of the INSM1 promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker for neuroendocrine differentiation in human lung tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS